Effectiveness of corifollitropin alfa used for ovarian stimulation of poor responder patients

Figures & data

Table 1 Demographic data and stimulation outcome

Parameters	Group A corifollitropin + rFSH	Group B clomiphene + rFSH	Odds ratio/95% confidence intervals	P-value
No of patients	42	43
Mean age ± SD	40.3±3.9	40.9±2.6	1.00 (0.54–1.85)	0.88
Mean BMI ± SD	25.1±1.9	24.9±2.1	1.03 (0.51–2.07)	0.92
No of canceled patients (%)	5 (11.9)	4 (9.3)	1.27 (0.32–5.09)	1.00
No of patients with egg retrieval	37	39	0.97 (0.52–1.80)	0.92
Duration of stimulation (days)	13.3±4.5	12.4±2.2	1.13 (0.46–2.76)	1.00
Estradiol level on HCG day (pg/mL)	1,020±580	995±658	1.08 (0.68–1.70)	0.82
Endometrial thickness on HCG day (mm)	10.6±2.4	10.2±2.1	1.09 (0.41–2.89)	1.00

Note: No statistically significant differences were observed between both groups.

Abbreviations: BMI, body mass index; HCG, human chorionic gonadotropin; rFSH, recombinant follicle-stimulating hormone; SD, standard deviation.

Table 2 Embryological characteristics

Parameters	Group A corifollitropin + rFSH	Group B clomiphene + rFSH	Odds ratio/95% confidence intervals	P-value
No of patients with egg retrieval	37	39	0.97 (0.52–1.80)	0.92
No of recovered oocytes (mean ± SD)	114 (3.0±0.8)	109 (2.7±0.7)	0.96 (0.57–1.63)	0.88
No of mature inseminated oocytes (%) mean ± SD	92 (80.7) (2.5±0.8)	94 (86.2) (2.4±0.8)	1.03 (0.61–1.77)	0.88
No of fertilized 2PN oocytes (%) mean ± SD	72 (78.2) 1.9±0.6	74 (78.7) 1.8±0.6	1.04 (0.59–1.83)	0.86
No of cleaving embryos (%) mean ± SD	66 (91.6) 1.8±0.6	67 (90.5) 1.7±0.7	1.04 (0.59–1.83)	0.88

Note: No statistically significant differences were observed between both groups.

Abbreviations: rFSH, recombinant follicle-stimulating hormone; SD, standard deviation.

Table 3 Clinical outcome

Parameters	Group A corifollitropin + rFSH	Group B clomiphene + rFSH	Odds ratio/95% confidence intervals	P-value
No of patients who underwent embryo transfer	37	39	0.97 (0.52–1.80)	0.92
Mean number of embryos transferred ± SD	1.8±0.6	1.7±0.7	1.04 (0.59–1.83)	0.88
Clinical pregnancies per embryo transfer (%)	8 (21.6)	7 (17.9)	0.83 (0.27–2.51)	0.78
Clinical pregnancies per started cycle (%)	19	16.3	0.85 (0.28–2.56)	1.00
Implantation rate (%)	9/61 (14.7)	9/67 (13.4)	0.91 (0.33–2.44)	1.00
Ongoing pregnancies per transfer (%)	2 (5.4)	2 (5.1)	0.94 (1.13–7.08)	1.00
Delivery rate per transfer (%)	5 (13.5)	4 (10.3)	0.76 (0.19–3.04)	0.73
Miscarriage rate per pregnancy (%)	1 (12.5)	1 (14.2)	1.14 (0.06-21.87)	1.00

Note: No statistically significant differences were observed between both groups.

Abbreviations: rFSH, recombinant follicle-stimulating hormone; SD, standard deviation.