Figures & data
Figure 1 (A) Cross sections of the uterus showing the veins (v) and arteries (a) within the mesometrium stained with H&E. Corresponding to the two uterine horns there are two main utero-ovarian arteries and veins that are positioned in the mesometrium parallel to each uterine horn. Arcuate vessels run from the main vessels and form loops that are also positioned in the mesometrium. (B) At the same magnification, a cross section through the uterus provides a view on a fraction of the uterus showing the myometrial vessels (radial, a, v) connecting the arcuate vessels to the uterine wall. Arrow 1 marks the myometrium, and arrow 2 indicates the endometrium.
Table 1 Vessel diameters measured after 7 days
Table 2 Vessel diameter measured after 13 days
Figure 2 Uterine horns freshly dissected from non-pregnant rats at 13 days (six days after seven-day exposure to reagent release from the inserted osmotic pumps). Top: saline treated animal; middle: His-PP13 treated animal; bottom: rPP13 treated animal.
Figure 3 Long-term effects of rPP13 and His-PP13 on the diameters of uterine veins: MUV, AUV, and RUV. Data are reported as median ± IQR.
Figure 4 Long-term effects of rPP13 and His-PP13 on the diameters of uterine arteries: MUA, AUA, and RUA. Data are reported as median ± IQR.
Figure 5 Integrated effect of PP13 on the vascular system. A schematic description integrating the impact of PP13 on the vascular system that shows how PP13 could influence the vascular system and prime it to be ready for its increased role in pregnancy.
