Transvaginal sonographic evaluation at different menstrual cycle phases in diagnosis of uterine lesions

Figures & data

Table 1 Sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) of transvaginal sonography on different days of the menstrual cycle

Day of cycle	N	Yes*	Sensitivity	Specificity	PPV	NPV
1–4	495	11	28.2%	100%	100%	94%
5–8	490	16	41.2%	100%	100%	95%
9–12	480	26	66.6%	100%	100%	97%
13–15	471	35	89.7%	100%	100%	99%
16–19	467	39	100%	100%	100%	100%
20–24	476	30	76.9%	100%	100%	98%
25–30	487	19	48%	100%	100%	95.8%

Note:

* Refers to the number on transvaginal sonography, on which the lesions were seen.

Abbreviation: N, number.

Table 2 Sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) of transvaginal sonography compared with sonohysterography

Day of cycle	Sensitivity	Specificity	PPV	NPV
1–4	26.8%	98%	84.6%	80%
5–8	39%	98%	88.8%	82.7%
9–12	63%	98%	92.8%	88.8%
13–15	85.3%	98%	94.5%	95.2%
16–19	95%	98%	95%	98.2%
20–24	73.1%	98%	93.7%	91.6%
25–30	46.3%	98%	90.4%	84.5%

Figure 1 Heat map of outcomes of various studies assessing transvaginal sonography (complementary to Table 3*).

Note: *Rows 1–10 correlate with studies 1–10 in Table 3.
Abbreviations: PPV, positive predictive value; NPV, negative predictive value.

Table 3 Sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) of transvaginal sonography (TVS) in different studies (complementary to Figure 1*)

Study	Time TVS performed	Sensitivity	Specificity	PPV	NPV
1. Shalev and Dicker^Citation13	Day 9–13	100%	96.3%	91.3%	100%
2. Dueholm et al^Citation22	Without relationship to phase of cycle	69%	83%	71%	82%
3. Guven et al^Citation20	Without relationship to phase of cycle	78%	38%	61%	59%
4. Alborzi et al^Citation19	Without relationship to phase of cycle	72%	92%	94%	65%
5. Kelekci et al^Citation21	Early proliferative phase	56.2%	72%	56.3%	72%
6. Loverro et al^Citation15	Day 6–10	84.5%	98.7%	98%	89.2%
7. Valentin^Citation23	Without relationship to phase of cycle	69%	83%	71%	82%
8. Grimbizis et al^Citation24	Without relationship to phase of cycle	44.8%	77.5%	–	–
9. Present study	Day 16–19	95%	98%	95.1%	98%
10. Shalev et al^Citation25	Follicular phase	71.4%	100%	100%	97.1%

Note:

* Studies 1–10 correlate with rows 1–10 in Figure 1.

ShalevJDickerDPredictive values of transvaginal sonography in specifying bicornuate and septate uterus?Fertil Steril200379125412738533

 PubMed Web of Science ®Google Scholar

DueholmMLundorfEHansenESLedertougSOlesenFEvaluation of the uterine cavity with magnetic resonance imaging, transvagi-nal sonography, hysterosonographic examination, and diagnostic hysteroscopyFertil Steril20017635035711476785

 PubMed Web of Science ®Google Scholar

GuvenMABeseTDemirkiranFIdilMMgoyiLHydrosonography in screening for intracavitary pathology in infertile womenInt J Gynaecol Obstet20048637738315325856

 PubMed Web of Science ®Google Scholar

AlborziSParsanezhadMEMahmoodianNAlborziMSonohysterography versus transvaginal sonography for screening of patients with abnormal uterine bleedingInt J Gynaecol Obstet200796202317187802

 PubMed Web of Science ®Google Scholar

KelekciSKayaEAlanMAlanYBilgeUMollamahmutogluLComparison of transvaginal sonography, saline infusion sonography, and office hysteroscopy in reproductive-aged women with or without abnormal uterine bleedingFertil Steril20058468268616169403

 PubMed Web of Science ®Google Scholar

LoverroGNappiLMeiLGiacomoantonioLCarrieroCTartagniMEvaluation of functional ovarian reserve in 60 patientsReprod Biomed Online2003720020414567892

 PubMedGoogle Scholar

ValentinLTransvaginal sonography in gynaecologyReviews in Gynaecological and Perinatal Practice200345057

 Google Scholar

GrimbizisGFTsolakidisDMikosTA prospective comparison of transvaginal ultrasound, saline infusion sonohysterography, and diagnostic hysteroscopy in the evaluation of endometrial pathologyFertil Steril2010942720272520462577

 PubMed Web of Science ®Google Scholar

ShalevJMeiznerIBar-HavaIDickerDMashiachRBen-RafaelZPredictive value of transvaginal sonography performed before routine diagnostic hysteroscopy for evaluation of infertilityFertil Steril20007341241710685552

 PubMed Web of Science ®Google Scholar