A Randomized Control Trial of 3 IU IV Oxytocin Bolus with 7 IU Oxytocin Infusion versus 10 IU Oxytocin Infusion During Cesarean Section for Prevention of Postpartum Hemorrhage

Figures & data

Table 1 Comparison of Age, Duration of Married Life and Period of Gestation Between Group 1 and Group 2

Parameters	Group 1		Group 2		p value*
	Mean	SD	Mean	SD
Age (yrs)	24.0	3.7	24.2	3.9	0.766
Duration of married life	4.6	3.6	4.6	3.5	0.957
Period of gestation	38.8	2.4	38.8	1.8	0.936

Note: *If the p-value is equal to or lesser than 0.05 then the result is considered to be statistically significant.

Table 2 Comparison of Parity Between Group 1 and Group 2

Parity	Group 1		Group 2		p value*
	N	%	N	%
0	50	40.0%	45	36.0%	0.695
1	47	37.6%	51	40.8%
2	27	21.6%	26	20.8%
3	1	0.8%	3	2.4%
Total	125	100.0%	125	100.0%

Note: *If the p-value is equal to or lesser than 0.05 then the result is considered to be statistically significant.

Figure 1 CONSORT flow diagram.

Note: https://journals.plos.org/plosmedicine/article id=10.1371/journal.pmed.1000251Citation: Schulz KF, Altman DG, Moher D, for the CONSORT Group (2010) CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. PLoS Med 7(3): e1000251.Copyright: © 2010 Schulz et al. Creative Commons Attribution License.¹⁹

Table 3 Comparison of Pre-Operative (Pre-Op) and Post Operative (Post-Op) Hemoglobin in gm/dl and Difference in the Hemoglobin Levels in Group 1 and Group 2

Parameters		Group 1		Group 2		p value*	95% Confidence Interval
		Mean	SD	Mean	SD		Lower Bound	Upper Bound
Hemoglobin in gm/dl	Pre-Op	11.15	1.12	11.17	1.36	0.903	−0.33	0.29
	Post-Op	10.18	1.27	9.49	1.14	<0.001*	0.39	0.99
Difference in the hemoglobin levels in gm/dl		0.97	0.70	1.68	1.20	<0.001*	−0.95	−0.46

Note: *If the p-value is equal to or lesser than 0.05 then the result is considered to be statistically significant.

Table 4 Comparison of Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure and SPO2 Between Group 1 and Group 2

Parameters		Group 1		Group 2		p value*	95% Confidence Interval
		Mean	SD	Mean	SD		Lower Bound	Upper Bound
Heart rate	1 min	92.6	20.3	90.2	22.8	0.407	−3.3	8.2
	3 min	94.2	22.3	91.3	19.7	0.310	−2.8	8.8
	5 min	94.9	16.9	92.8	20.9	0.433	−3.1	7.3
	10 min	90.1	56.4	90.1	19.8	0.318	−2.5	7.6
Systolic pressure	1 min	118.2	17.7	116.3	16.9	0.423	−2.7	6.5
	3 min	116.9	18.5	114.2	18.3	0.296	−2.4	7.7
	5 min	115.0	15.6	112.6	15.7	0.265	−1.9	6.7
	10 min	116.2	15.7	114.1	14.1	0.269	−1.6	5.9
Diastolic blood Pressure	1 min	73.9	14.5	71.8	13.7	0.274	−1.7	5.9
	3 min	70.9	15.1	70.0	13.9	0.683	−3.2	4.8
	5 min	70.0	13.9	67.2	12.4	0.121	−0.8	6.5
	10 min	72.3	13.0	70.7	11.2	0.318	−1.5	4.6
SPO2	1 min	99.4	1.3	99.1	2.2	0.118	−0.1	0.9
	3 min	99.3	2.1	98.9	2.2	0.238	−0.2	0.9
	5 min	99.2	1.6	108.1	90.7	0.308	−26.2	8.3
	10 min	99.0	1.6	98.4	8.2	0.424	−0.9	2.1

Note: *If the p-value is equal to or lesser than 0.05 then the result is considered to be statistically significant.

Table 5 Comparison of ECG Changes, Adverse Effects and Use of Additional Uterotonics Between Group 1 and Group 2

Parameter	Group 1		Group 2		p value*
	N	%	N	%
ECG lead changes
1 MIN	0	0.0%	0	0.0%	–
3 MIN	0	0.0%	0	0.0%	–
5 MIN	0	0.0%	0	0.0%	–
10MIN	2	1.6%	1	0.8%	0.561
Adverse effect
Tachysystole	0	0.0%	0	0.0%	–
Nausea	4	3.2%	0	0.0%	0.151
Uneasiness in the chest/chest pain	1	0.8%	2	1.6%	0.561
Headache	0	0.0%	1	0.8%	0.478
PPH	0	0.0%	1	0.8%	0.478
Use of additional uterotonics
Yes	3	2.4%	3	2.4%	–
No	122	97.6%	122	97.6%
Total	125	100.0%	125	100.0%

Note: *If the p-value is equal to or lesser than 0.05 then the result is considered to be statistically significant.

Table 6 Comparison of the Uterine Tone Following the Extraction of the Baby Between Group 1 and Group 2

Parameters		Group 1		Group 2		p value*	95% Confidence Interval
		Mean	SD	Mean	SD		Lower Bound	Upper Bound
Tone of the uterus	1 MIN	3.46	0.58	3.29	0.79	0.056	0.00	0.34
	3 MIN	4.03	0.66	3.86	0.70	0.052	0.00	0.34
	5 MIN	4.58	0.54	4.25	0.66	<0.001*	0.18	0.48
	10MIN	4.93	0.29	5.10	3.63	0.607	−0.81	0.47

Note: *If the p-value is equal to or lesser than 0.05 then the result is considered to be statistically significant.

Schulz KF, Altman DG, Moher D. Updated Guidelines for Reporting Parallel Group Randomised Trials. PLoS Med. 2010;7(3):e1000251. https://journals.plos.org/plosmedicine/article.

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