Anti-Mullerian Hormone Changes Following Laparoscopic Ovarian Cystectomy: A Prospective Comparative Study

Figures & data

Table 1 Baseline Data

	LOC (N=26)	LM (N=20)	P value
Age (years)	33.5 ± 8.73	41.3 ± 5.77	0.001*
Parity	1 ± 0.99	1 ± 1.03	0.174
BMI	21.5 ± 3.29	24.9 ± 4.41	0.004*

Notes: Baseline data are presented. *P value < 0.05. Data are presented as mean ± SD or median ± SEM.

Table 2 Pathology of Women with Ovarian Cystectomy

Pathology	N=26
Endometriosis	4(15.4)
Mature cystic teratoma	8 (30.8)
Mucinous cystadenoma	4 (15.4)
Abscess	1 (3.8)
Follicular cyst	3(11.5)
Adenofibroma	5(19.2)
Endometriosis & adenofibroma	1 (3.8)

Notes: Pathology of women with ovarian cystectomy are presented. Data was presented as number (%).

Table 3 Changes in Serum AMH Levels Following LOC and LM

	LOC (N=26)	LM (N=20)	P value
AMH levels
Preoperative (AMH0)	3.5 ± 3.33	2.4 ± 2.72	0.250
Postoperative 7 days (AMH1)	2.4 ± 2.46	2.6 ± 3.28	0.788
Postoperative 2 months (AMH2)	2.6 ± 2.83	2.6 ± 3.11	0.957
Postoperative 6 months (AMH3)	1.6 ± 2.23	2.6 ± 3.60	0.414
AMH changes comparing to preoperative level
Postoperative 7 days (AMH1)	−1.1 ± 2.98	0.2 ± 1.44	0.079
Postoperative 2 months (AMH2)	−0.9 ± 3.20	0.1 ± 1.32	0.196
Postoperative 6 months (AMH3)	−1.7 ± 4.34	0.0 ± 1.81	0.136
AMH1 decrease ≥50% (N=7/46)	5 (19.2)	2 (10.0)	0.332
AMH2 decrease ≥50% (N=10/46)	6 (23.1)	4 (20.0)	0.547
AMH3 decrease ≥50% (N=8/30)	4 (36.4)	4 (21.0)	0.001*

Notes: Changes in serum AMH levels following LOC and LM were presented. *P value < 0.05.

Figure 1 Serial changes of serum AMH levels following LOC and LM. The serum AMH level, which barely changed in the LM group, abruptly decreased in the LOC group 1 week after surgery and had not recovered to pre-operative levels 6 months after surgery. However, in this group there were no statistically significant differences between AMH0 and AMH3.

Table 4 Correlation Between Changes in AMH and Clinical Characteristics

	AMH1 Decrease ≥50% (N=7/46)	P-value	AMH2 Decrease ≥50% (N=10/46)	P-value	AMH3 Decrease ≥50% (N=8/30)	P-value
Age		0.500		0.142		0.035*
< 39 yrs	3 (13.0)		3 (13.0)		2 (8.7)
≥ 39 yrs	4 (17.4)		7 (30.4)		6 (26.1)
BMI		0.207		0.043*		0.544
< 20	3 (27.3)		5 (14.3)		3 (27.3)
≥ 20	4 (11.4)		5 (21.7)		5 (14.3)

Notes: Correlation between changes in AMH and clinical characteristics was presented. *P value < 0.05.

Table 5 Correlation Between Changes in AMH and Clinical Characteristics Following LOC

	AMH1 Decrease ≥50% (N=5/26)	P-value	AMH2 Decrease ≥50% (N=6/26)	P-value		AMH3 Decrease ≥50% (N=4/11)	P-value
Age		0.580		0.332			0.182
< 39 yrs	3 (17.6)		3 (17.6)			2 (11.8)
≥ 39 yrs	2 (22.2)		3 (33.3)			2 (22.2)
BMI		0.580		0.084			0.105
< 20	2 (22.2)		4 (44.4)			3 (33.3)
≥ 20	3 (17.6)		2 (11.8)			1 (5.9)
Bilateral tumor		0.411		0.028*			0.001*
No	3 (15.8)		2 (10.5)			0 (0.0)
Yes	2 (28.6)		4 (57.1)			4 (57.1)
Tumor diameter		0.150		0.622			0.302
< 7 cm	2 (11.1)		4 (22.2)			4 (22.2)
≥ 7 cm	3 (37.5)		2 (25.0)			0 (0.0)

Notes: Correlation between changes in AMH and clinical characteristics following LOC was presented. *P value < 0.05.