Impact of IVF on the Timing and Symptoms of Menopause

Figures & data

Table 1 Characteristics of IVF and Non-IVF Patients

Characteristics	IVF (n = 50)	Non-IVF (n = 50)	p-value
Age (mean ± SD)	51.02 ± 2.42	52.76 ± 2.37	0.000*
Age of IVF	41.26 ± 2.32
Number of IVF cycle	2 (1–7)
Number of children	0.78 (0–2)	2.72 (1–6)	0.000**
Menarche (mean ± SD)	13 ± 0.94	12.32 ± 1.23	0.003*
Onset age of menopause	49.84	50.66	0.004
Smoking history			0.461***
Yes	5 (5%)	3 (3%)
No	45 (45%)	47 (47%)
Previous surgical history			0.011***
Yes	18 (18%)	7 (7%)
No	32 (32%)	43 (43%)
Education			0.000***
Senior high school	–	15 (15%)
Diploma	42 (42%)	17 (17%)
Magister	4 (4%)	14 (14%)
Doctor	4 (4%)	4 (4%)

Notes: *Independent Samples t-test, **Mann–Whitney test, ***Chi-square.

Table 2 Comparison Between IVF and Non-IVF Patients

Variable	IVF (n = 50)*	Non-IVF (n = 50)	p**
Somatic symptoms	51.59	49.41	0.701
Psycho symptoms	48.04	52.96	0.386
Urogenital symptoms	44.33	56.67	0.030

Note: *Mean, **Mann–Whitney test.

Table 3 Multivariate Analysis of Symptoms of IVF and Non-IVF Patients

Variable	Unstandardized β Coefficient (95% CI)	p-value*
Somatic Symptoms
Age	0.133 (0.005–0.261)	0.042
Number of children	−0.161 (−0.435–0.113)	0.247
Menarche	0.081 (−0.215–0.378)	0.587
Previous surgical history	−0.032 (−0.769–0.705)	0.932
Education	−0.061 (−0.468–0.346)	0.767
Psycho Symptoms
Age	0.119 (−0.032–0.269)	0.120
Number of children	0.000 (−0.322–0.323)	0.998
Menarche	−0.35 (−0.384–0.313)	0.841
Previous surgical history	0.322 (−0.544–1.189)	0.462
Education	−0.449 (−0.928–0.030)	0.066
Urogenital Symptoms
Age	0.072 (−0.047–0.192)	0.232
Number of children	0.082 (−0.174–0.338)	0.525
Menarche	0.041 (−0.236–0.318)	0.769
Previous surgical history	−0.223 (−0.911–0.466)	0.525
Education	0.072 (−0.309–0.452)	0.708

Note: *Data analysis using linear regression, significant p<0.05.