Clinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy

Figures & data

Table 1 Aneuploidy Prenatal Screening Results and Delivery Outcomes of 13 Cases of Non-Invasive Prenatal Screening High-Risk Single Fetus Pregnancy Women

Number	Advanced Age or Not	Results of NIPT	Results of Diagnosis	Consistency of NIPT with Diagnostic Results	Delivery Outcomes
1	No	High risk Trisomy 21	46, XN	No	Live birth
2	Yes	High risk Trisomy 21	46, XN	No	Live birth
3	Yes	High risk Trisomy 21	46, XN	No	Live birth
4	Yes	High risk Trisomy 21	47, XN, +21	Yes	Induced labour
5	Yes	High risk Trisomy 21	47, XN, +21	Yes	Induced labour
6	No	High risk Trisomy 21	47, XN, +21	Yes	Induced labour
7	Yes	High risk Trisomy 21	47, XN, +21	Yes	Induced labour
8	No	High risk Trisomy 21	47, XN, +21	Yes	Induced labour
9	Yes	High risk Trisomy 18	47, XN, +18	Yes	Multiple malformations induced labor
10	Yes	High risk Trisomy 18	47, XN, +18	Yes	Induced labour
11	Yes	High risk Trisomy 18	46, XN	No	Live birth
12	No	High risk Trisomy 13	46, XN	No	Live birth
13	No	High risk Trisomy 13	46, XN	No	Live birth

Table 2 Aneuploidy Prenatal Screening Results and Delivery Outcomes of 7 Cases of Non-Invasive Prenatal Screening High-Risk Twins Pregnancy Women

Number	Advanced Age or Not	Chorionic Properties	Results of NIPT	Results of Diagnosis	Consistency of NIPT with Diagnostic Results	Delivery Outcomes
1	No	Dichorionic	High risk Trisomy 21	A: 46, XN B: 46, XN	No	Twin live births
2	No	Dichorionic	High risk Trisomy 21	A: 46, XN B: 47, XN, +21	Yes	Single live birth after reduction
3	No	Dichorionic	High risk Trisomy 21	A: 46, XN B: 47, XN, +21	Yes	Single live birth after reduction
4	Yes	Dichorionic	High risk Trisomy 21	A: 46, XN B: 47, XN, +21	Yes	Single live birth after reduction
5	No	Dichorionic	High risk Trisomy 21	A: 46, XN B: 47, XN, +21	Yes	Single live birth after reduction
6	No	Dichorionic	High risk Trisomy 21	A: 46, XN B: 47, XN, +21	Yes	Single live birth after reduction
7	No	Dichorionic	High risk Trisomy 18	A: 46, XN B: 47, XN, +18	Yes	Twin live births with postnatal death of trisomy 18

Table 3 Efficiency of NIPT in Detecting Aneuploidy of IVF Conceived Fetus

Number	Form	Sensitivity	Specificity	Positive Predictive Value	False Positive	Negative Predictive Value
1	IVF conceived fetus	100	99.77	65	0.23	100
2	IVF single fetus conceived	100	99.72	53.85	0.28	100
3	IVF twin pregnancy	100	99.89	85.71	0.11	100

Table 4 Efficiency of NIPT for Trisomy 21/18/13 in IVF Conceived Fetuses

Number	Form	Single or Twin	Sensitivity	Specificity	Positive Predictive Value	False Positive	Negative Predictive Value
1	Trisomy 21	Single and twin	100	99.87	71.43	0.13	100
2	Trisomy 21	Single birth	100	99.86	62.5	0.14	100
3	Trisomy 21	Twin birth	100	99.89	83.33	0.11	100
4	Trisomy 18	Single and twin	100	99.97	75	0.03	100
5	Trisomy 18	Single birth	100	99.95	66.67	0.05	100
6	Trisomy 18	Twin birth	100	100	100	0	100
7	Trisomy 13	Single and twin	100	99.94	99.94	0.06	100
8	Trisomy 13	Single birth	100	99.91	99.91	0.09	100