Primary Lung Cancer After Treatment for Breast Cancer

Figures & data

Table 1 Standard Incidence Ratios and 95% Confidence Intervals for Subsequent Primary Tumor in Breast Cancer Patients Who Lived Longer Than 10 Years

Second Primary Cancer Sites	Standard Incidence Ratio	95% Confidence Interval
All sites	1.42	1.39–1.44
Soft tissue sarcoma*	10.75	8.16–13.89
Bone	2.66	1.73–3.89
Myeloid leukaemia	2.11	1.78–2.49
Esophagus	2.09	1.80–2.42
Thyroid gland	1.86	1.57–2.19
Skin cancer except for melanoma	1.77	1.67–1.87
Ovary	1.75	1.63–1.88
Lung	1.68	1.59–1.78
Stomach	1.49	1.38–1.62
Leukemia	1.43	1.28–1.60
Corpus uteri	1.40	1.30–1.50
Oral cavity and pharynx	1.40	1.21–1.61
Melanoma	1.39	1.25–1.54
Non-Hodgkin’s lymphoma	1.39	1.26–1.54
Pancreas	1.32	1.20–1.44
Colorectal	1.30	1.24–1.36
Bladder	1.30	1.17–1.45
Kidney	1.27	1.14–1.42

Notes: *Soft tissue sarcoma of the upper limbs and chest including the shoulders. Reproduced wih permission from Mellemkjaer L, Friis S, Olsen JH, et al. Risk of second cancer among women with breast cancer. Int J Cancer.. 2005;118(9):2285–2292. Copyright © 2005 Wiley‐Liss, Inc.⁴

Table 2 Relevant Literatures About the Risk of Subsequent Primary Lung Cancer After Breast Cancer

Author	Publication Year	Database/Region	Period	Sample Size	Follow-Up (Year)	SIR	95% CI
Dorffel^Citation14	2000	GDR/German	1976–1988	5485	–	1.65	0.93–2.73
Rubino^Citation15	2000	IGR/France	1973–1992	4416	0–10+	1.0	0.4–2.1
Evans^Citation12	2001	South east of England	1961–1995	145,677	0–15+	1.60	1.23–2.09
Levi^Citation16	2003	Switzerland	1974–1998	9729	0–5+	1.04	0.72–1.46
Mellemkjaer^Citation4	2006	International Oncology Database	1943–2000	525,527	0–10+	1.50	1.01–2.23
Lee^Citation17	2008	TNCR/Taiwan, China	1979–2003	53,783	0–10+	1.27	0.57–2.84
Schaapveld^Citation13	2008	Netherlands	1989–2003	58,068	0–15+	1.22	1.08–1.36
Rosso^Citation18	2009	PCR/Italy	1985–2003	9233	–	0.80	0.54–1.15
Yi^Citation19	2013	ACC/USA	1979–2007	4198	2–30.5	1.84	1.25–2.42
Utata^Citation11	2014	NPCR/Japn	1985–2007	174,477	–	1.41	1.13–1.73
Hamilton^Citation20	2015	Canada	1989–2005	12,836	0–10+	1.08	0.91–1.27
Bazire^Citation21	2017	Paris, France	1981–2000	17,745	2–29	1.39	1.13–1.72
Silverman^Citation22	2017	INCR/Israel	1990–2006	46,090	–	1.22	1.08–1.35
Lin^Citation23	2018	TNHI and TNCR/Taiwan, China	2000–2011	88,446	0–3+	1.32/1.25	0.81–2.16/0.66–2.36
Wang^Citation9	2018	SEER/USA	2000–2014	6269	0–10+	1.03	1.00–1.06

Abbreviations: GDR, German Democratic Republic; IGR, Institute Gustave Roussy; TNCR, Taiwan National Cancer Registry; PCR, Piedmont Cancer Registry; ACC, Anderson Cancer Center; NPCR, Nagasaki Prefecture Cancer Registry; INCR, Israel National Cancer Registry; TNHI, Taiwan National Health Insurance; SEER, Surveillance, Epidemiology and End Results; DBCG, Danish Breast Cancer Cooperative; SIR, Standard incidence ratio; CI, confidence interval; -, not reported.

Table 3 Relevant Literatures About the Association Between Radiotherapy for Breast Cancer and Risk for Subsequent Lung Cancer

Author	Publication Year	Database/Region	Period	Type of Study	Sample Size	RR/OR	95% CI
Neugut^Citation27	1994	CTR/USA	–	CCS	1164	2.80	1.20–6.40
Obedian^Citation28	2000	YNHS/ USA	1970–1990	CS	2416	0.73	0.29–1.81
Zablotska^Citation29	2003	SEER/ USA	1973–1998	CS	194981	1.09	0.97–1.22
Zablotska^Citation29	2003	SEER/ USA	1980–1998	CS	65560	1.40	1.11–1.75
Ford^Citation7	2003	ACC/ USA	1960–1997	CCS	580	1.03	0.74–1.43
Deutsch^Citation30	2003	Pittsburgh, USA	1971–1974	RCT	1665	2.45	1.07–5.64
Deutsch^Citation30	2003	Pittsburgh in USA	1976–1984	RCT	1850	0.85	0.39–1.84
Roychoudhuri^Citation31	2004	TCR/South east of England	1961–2000	CS	64782	1.10	0.92–1.31
Levi^Citation32	2006	SVCR/Switzerland	1978–1998	CS	6119	1.91	0.90–4.07
Schaapveld^Citation13	2008	Netherlands	1989–2003	CS	14678	2.31	1.15–4.60
Schaapveld^Citation13	2008	Netherlands	1989–2003	CS	43390	0.94	0.72–1.22
Andersson^Citation33	2008	DBCG/Denmark	1977–2001	CS	31818	1.33	1.00–1.77
Bazire^Citation21	2017	Paris, France	1981–2000	CS	17745	2.11	0.97–4.60
Huang^Citation2	2017	LHID/Taiwan, China	2000–2010	RCT	7408	9.62	3.56–26.00
Withrow^Citation3	2017	SEER/USA	1992–2008	CS	52556	1.33	1.10–1.60
DiMarzio^Citation1	2018	New York, USA	2000–2014	CS	3918	4.98	2.06–12.05
DiMarzio^Citation1	2018	New York, USA	2000–2014	CS	6218	1.59	0.59–4.32

Abbreviations: CTR, Connecticut Tumor Registry; YNHH, Yale New Haven Hospital; TCR, Thames Cancer Registry; SEER, Surveillance, Epidemiology and End Results; ACC, Anderson Cancer Center; SVCR, Swiss Vaud Cancer Registry; DBCG, Danish Breast Cancer Cooperative Group; LHID, Longitudinal Health Insurance Database; CCS, case-control study; CS, cohort study; RCT, randomized controlled study; RR, relative risk; OR, odds ratio; CI, confidence interval; -, not reported.

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