Clinical Significance of Application of Chromosomal Karyotyping of Villus Tissues

Figures & data

Figure 1 Analysis of the abnormal number of villus chromosomes detected in 294 patients. Abnormal distribution of chromosome number in abortion tissue of 294 patients, including 47, +16 (62 cases); 47, +22 (18 cases); 47, +13 (12 cases);47, +15 (10 cases);47, +21 (11 cases); Triploid (23 cases); 45, XO (35 cases); Deletion/Duplication(46 cases), and so on.

Table 1 Comparison of Proportions of Abnormal Karyotypes Among Different Age Groups

Age (Years Old)	≤29	30–35	≥36
N	252	209	55
Normal karyotype (n/%)	110 (43.6)	80 (38.3)	11 (20.0)
Abnormal karyotype (n/%)	142 (56.4)	111 (62.7)	44 (80.0)

Table 2 Chromosomal Abnormalities in Couples and Abnormal Embryonic Karyotypes

	Peripheral Blood Chromosomes in Couples	Embryonic Chromosomes
Wife	Robertsonian translocation	47, +3
	inv(9)(p12q13)	Triploid
	inv(9)(p12q13)	48,+8, +8
	inv(9)(p12q13)*2	47,+13
	inv(14)(p13q13)	45,X0
	46,XX,9qh+
	t(3;5)(p13; p14)	Partial duplication at p arm of chromosome 3, and partial deletion at p arm of chromosome 5
Husband	inv(9)(p12q13)	45,-21 (suspected chimera)
	45,XY,rob(13;14)(q10; q10)	47,XX,+14
Both spouses	46,xx,9qh+/46,xy,14ps+	47,XX,+14

Abbreviations: HLPA, high-throughput ligation-dependent probe amplification; MAPA, multiplex ligation-dependent probe amplification; SD, standard deviation.