Association Between Endometritis and Endometrial Polyp: A Mendelian Randomization Study

Figures & data

Figure 1 Illustrates the conceptual and analytical flow of this study.

Table 1 Instrumental SNPs from GWAS on Endometritis and Endometrial Polyp

				Exposure (Endometritis)			Outcome (Endometrial Polyp)
Instrumental SNP	Effect Allele	Chr	Position	Beta	SE	P-value	β	SE	P-value
rs10255973	A	7	153,616,857	0.17	0.036	1.66e-06	2.07e-04	1.61e-04	0.20
rs1053102	G	17	48,188,755	0.17	0.036	1.98e-06	−2.56e-05	1.69e-04	0.88
rs11578938	T	1	199,892,279	−0.14	0.031	4.30e-06	−5.10e-05	1.49e-04	0.73
rs62366729	A	5	91,911,520	0.21	0.044	1.22e-06	−2.04e-04	1.99e-04	0.31

Abbreviations: SE, standard error; SNP, single‐nucleotide polymorphism; β, β coefficient.

Figure 2 Association of genetic susceptibility to various allergic diseases with endometritis of endometrial polyp. Statistical significance: p < 0.05.

Abbreviations: IVW, inverse-variance weighted; MR, Mendelian randomization; OR, odds ratio.

Table 2 Heterogeneity Test and Horizontal Pleiotropy Test

		Heterogeneity Test			Horizontal Pleiotropy Test
Exposure	Outcome	Method	Cochran’s Q	Q_ pval	Egger_Intercept	SE	P-val
Endometritis	Endometrial Polyp	IVW	7.01	0.32	0.09	0.05	0.10
		MR-Egger	2.96	0.71

Note: Statistical significance: p < 0.05.

Abbreviations: IVW, inverse-variance weighted; MR, Mendelian randomization; SE, standard error.