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ORIGINAL RESEARCH

Alveolar Soft Part Sarcoma in the Female Genital Tract: Case Series with Literature Review and SEER Database Analysis

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Pages 17-30 | Received 13 Sep 2023, Accepted 13 Dec 2023, Published online: 05 Jan 2024

Figures & data

Figure 1 A flowchart outlining the criteria for patient eligibility.

Figure 1 A flowchart outlining the criteria for patient eligibility.

Table 1 Summary of Clinicopathological Features of ASPS in the Female Genital Tract at Our Institution

Figure 2 Histological findings and the results of special staining and immunostaining in case 3 are as follows: The tumor cells exhibit an organoid pattern (A) or a nest-like arrangement (B), with delicate fibrovascular septa separating them. PAS staining reveals the presence of purplish-red crystals in the cytoplasm (indicated by the yellow arrow) (C). Immunostaining shows diffuse positivity for TFE3 (D), while HMB-45 (E) and Melan-A (F) are negative. The original magnification for all images is 200×.

Figure 2 Histological findings and the results of special staining and immunostaining in case 3 are as follows: The tumor cells exhibit an organoid pattern (A) or a nest-like arrangement (B), with delicate fibrovascular septa separating them. PAS staining reveals the presence of purplish-red crystals in the cytoplasm (indicated by the yellow arrow) (C). Immunostaining shows diffuse positivity for TFE3 (D), while HMB-45 (E) and Melan-A (F) are negative. The original magnification for all images is 200×.

Figure 3 Fluorescence in situ hybridization demonstrates a break-apart signal indicating TFE3 rearrangement in case 3.

Figure 3 Fluorescence in situ hybridization demonstrates a break-apart signal indicating TFE3 rearrangement in case 3.

Figure 4 A diagrammatic representation is provided to illustrate the two variant gene fusions identified through targeted RNA sequencing analysis. The PRCC-TFE3 transcript consists of PRCC exon 7 fused to exons 2 of TFE3 in case 3.

Figure 4 A diagrammatic representation is provided to illustrate the two variant gene fusions identified through targeted RNA sequencing analysis. The PRCC-TFE3 transcript consists of PRCC exon 7 fused to exons 2 of TFE3 in case 3.

Table 2 Summary of Clinicopathological Features of Previously Published Cases of ASPS in the Female Genital Tract

Table 3 Summary of Demographic and Treatment Information for ASPS Female Patients in the SEER Database

Table 4 Univariate and Multivariate Survival Analysis for ASPS Patients in the SEER Database