Efficacy of Dan’e Fukang Soft Extract in Moderate Ovarian Hyperstimulation Syndrome for Concurrent Treatment of Blood and Fluid Guided by the “Triple Prevention” Principle

Figures & data

Figure 1 Flowchart of the case screening process.

Table 1 Comparison of the General Characteristics Between the Two Groups of Patients

Indicators	Treatment Group (n = 1002)	Control Group (n = 1243)	P
Age (Year)	31 (29, 33)	31 (28, 33)	0.413
Body mass index (kg/m^2)	23.00 (20.94, 25.61)	23.23 (20.96, 25.70)	0.597
The years of infertility (Year)	3 (2, 5)	3 (2, 5)	0.532
The type of infertility (the number of cases, %)
Primary	565 (56.39%)	697 (56.03%)	0.882
Secondary	437 (43.61%)	546 (43.93%)
The infertility factors (the number of cases, %)
Fallopian tube factor	493 (49.20%)	593 (47.71%)	0.481
The male partner factor	264 (26.35%)	265 (21.32%)	0.986
Endometriosis	20 (1.99%)	30 (2.41%)	0.505
Polycystic ovary syndrome	64 (6.39%)	78 (6.28%)	0.914
Unknown cause	125 (12.48%)	187 (15.04%)	0.975
The ovarian hyperstimulation protocol
The long regimen	335 (33.43%)	395 (31.78%)	0.336
The short regimen	201 (20.06%)	253 (20.35%)	0.863
Gonadotropin-releasing hormone antagonist regimen	255 (25.45%)	352 (28.32%)	0.128
The micro-stimulation protocol	7 (0.70%)	4 (0.32%)	0.204
The extra-long regimen	97 (9.68%)	120 (9.65%)	0.983
The simple Gn regimen	101 (10.08%)	117 (9.42%)	0.596
The E2 on the initiation day	45.35 (37.00, 56.13)	44.00 (35.20, 56.00)	0.213
The FSH on the initiation day	7.3 (6.1, 8.6)	7.2 (5.9, 8.5)	0.105
The LH on the initiation day	3.33 (2.30, 4.70)	3.2 (2.27, 4.50)	0.307
The P on the initiation day	0.54 (0.41, 0.67)	0.55 (0.42, 0.69)	0.225
The total Gn dosage	3000 (2475, 3825)	3000 (2475, 3825)	0.935
The Gn initiation dosage	225 (225, 300)	225 (225, 300)	0.220
The days of Gn administration	11 (10, 12)	11 (10, 12)	0.191
The E2 on the trigger day	2083.85 (1542.30, 2815.60)	2234.30 (1645.20, 2793.30)	0.093
The LH on the trigger day	0.80 (0.60, 1.70)	0.70 (0.60, 1.70)	0.555
The P on the trigger day	0.74 (0.56, 1.07)	0.74 (0.57, 1.05)	0.785

Notes: “P” represents the comparison of different indicators between before and after treatment in the same group.

Abbreviations: Gn, gonadotropin; FSH, follicle stimulating hormone; LH, luteotropic hormone; E2, estradiol.

Table 2 Comparison of the Indicators Before and After Treatment in the Two Groups of Patients

Indicators	Treatment Group (1002)	Control Group (1243)	P
The volume of pelvic ascites on the oocyte retrieval day (mL)	5.66 (4.97, 6.30)	5.65 (0.23, 6.05)	> 0.05
The volume of pelvic ascites during the menstrual cycle after oocyte retrieval (mL)	3.20 (2.90, 3.06)	4.78 (4.08, 5.50)	< 0.05
The maximum ovarian diameter on the oocyte retrieval day (cm)	6.66 (6.19, 7.13)	6.72 (6.13, 7.27)	> 0.05
The maximum ovarian diameter during the menstrual cycle after oocyte retrieval (cm)	4.69 (4.42, 4.95)	5.44 (5.29, 5.61)	< 0.05
The incidence of dysmenorrhea after oocyte retrieval (%)	20.36 (204/1002)	30.57 (380/1243)	< 0.05

Notes: “P” represents the comparison of different indicators between before and after treatment in the same group.