Case Report: A Rare Case of Primary Angiosarcoma of the Cervix with a Literature Review

Figures & data

Figure 1 Grossly, the uterine presented a spongy appearance with and necrosis and ulceration.

Figure 2 The tumor cells show vascular differentiation containing erythrocytes and mitosis (A)×40, (B)×100).

Figure 3 FISH showed YWHAE translocation proportion was 7 percent (≥30% is defined as positive).

Table 1 Summary of Cases with Primary Angiosarcoma of the Uterine Cervix

Case	Author	Region	Age	Clinical Manifestation	Imaging Findings
1^Citation7	Ohayi,2013	Nigeria	65	Foul smelling brownish vaginal discharge	Abdominal ultrasound: a 8.84cm x 7.6cm irregular hypoechoic cervical mass invading the bladder
2^Citation5	Shah,2020	U.K.	43	Heavy vaginal bleeding	MRI: a 5.6 cm mass in endocervical canal
Case	Pathological Features		IHC	Genetic Testing	Treatment & Prognosis
1^Citation7	Vasoformative entity composed of anastomosing vascular channels lined by endothelial cells with pleomorphism and hyperchromasia.		N/A	N/A	EUA and biopsy; died 5 days after EUA
2^Citation5	Diffuse sheets and nests of spindled and epithelioid cells, moderate to severe nuclear atypia, abortive vascular channels throughout; mitotically active; foci of necrosis		CD34 and CD31 diffuse cytoplasmic positive; ERG and cyclin D1 diffuse nuclear staining; D2-40 focal membranous positivity; WT1 focal nuclear immunoreactivity.	YWHAE-NUTM2 genetic fusion negative	Cervical biopsies; radical hysterectomy with pelvic lymphadenectomy; adjuvant chemotherapy with weekly paclitaxel; No evidence of death

Abbreviations: EUA, Examination Under Anaesthesia; IHC, Immunohistochemistry, N/A, Not applicable.

Ohayi SA, Ezugwu EC, Aderibigbe AS, Udeh EI. Angiosarcoma of the cervix: a case and literature review. Niger J Med. 2013;22(4):362–364.

 PubMedGoogle Scholar

Shah VI, Gl R, Thompson IW, Sumathi VP, McCluggage WG. Primary angiosarcoma of the cervix: case report of a rare lesion. Int J Gynecol Pathol. 2020;39(1):97–102. doi:10.1097/PGP.0000000000000567

 PubMed Web of Science ®Google Scholar