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ORIGINAL RESEARCH

Performance Evaluation of Noninvasive Prenatal Testing in Screening Chromosome Disorders: A Single-Center Observational Study of 15,304 Consecutive Cases in China

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Pages 563-573 | Received 19 Dec 2023, Accepted 20 Mar 2024, Published online: 29 Mar 2024

Figures & data

Figure 1 Flowchart of noninvasive prenatal test (NIPT) results and clinical outcome of pregnant women undergoing screening for fetal chromosome disorders between 2017 and 2022.

Abbreviations: SCA, sex-chromosomal abnormalities; CNV, copy number variant; TP, true positive; FP, false positive.
Figure 1 Flowchart of noninvasive prenatal test (NIPT) results and clinical outcome of pregnant women undergoing screening for fetal chromosome disorders between 2017 and 2022.

Table 1 Demographic Characteristic of Pregnant Women Undergoing Noninvasive Prenatal Testing (NIPT) for Fetal Chromosome Disorders Between 2017 and 2022

Table 2 Pregnancy Outcomes of True Positive Cases Confirmed by Confirmatory Invasive Testing and Follow-Up Results

Table 3 Performance of Noninvasive Prenatal Testing (NIPT) in Detecting Fetal Chromosome Disorders in Pregnancies with Outcome Data

Table 4 Performance of Noninvasive Prenatal Testing in Detection of Abnormalities in High-Risk Pregnancies and Low-Risk Pregnancies

Table 5 Performance of Noninvasive Prenatal Testing in Detection of Abnormalities in Singleton Pregnancy and Twin Pregnancy Groups

Table 6 Analysis of Biological Factors Causing 107 False-Positive Results