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ORIGINAL RESEARCH

Systemic Lupus Erythematosus and Pregnancy Complications and Outcomes: A Mendelian Randomization Study and Retrospective Validation

, , & ORCID Icon
Pages 891-902 | Received 26 Jan 2024, Accepted 11 May 2024, Published online: 18 May 2024

Figures & data

Figure 1 Study design flowchart of the Mendelian randomization study.

Figure 1 Study design flowchart of the Mendelian randomization study.

Table 1 Data Sources of This Study

Table 2 Two-Sample Mendelian Randomization Estimations Showing the Effects, Heterogeneity and Horizontal Pleiotropy of SLE on the Risk of Pregnancy Complications or Outcomes

Figure 2 Mendelian randomization estimates of SLE on the risk for pregnancy complications and outcomes. OR, Odds ratio; CI, Confidence interval; IVW, inverse-variance weighted; IVW (fixed), fixed-effects inverse-variance weighted; MR-PRESSO, MR-pleiotropy residual sum and outlier.

Figure 2 Mendelian randomization estimates of SLE on the risk for pregnancy complications and outcomes. OR, Odds ratio; CI, Confidence interval; IVW, inverse-variance weighted; IVW (fixed), fixed-effects inverse-variance weighted; MR-PRESSO, MR-pleiotropy residual sum and outlier.

Table 3 Clinical Data on the Correlation Between SLE and Six Pregnancy Complications or Outcomes

Data Sharing Statement

All data generated or analysed during this study are included in this published article and its Supplementary Information Files.