Yolk Sac Tumor of the Ovary in Mosaic 46XX Turner Syndrome

Figures & data

Figure 1 Patient’s physical stature. (A) Patient has normal stature with height 170 cm; (B) Breast development shows Tanner 5; (C) Pubic hair development shows Tanner 4.

Figure 2 Patient’s abdominal ultrasonography. (A) Suspected solid ovarian mass with colour Doppler +1; (B) Free fluid present on Morrison pouch.

Figure 3 Patient’s chromosomal analysis. (A) Patient’s chromosome was 46XX; (B) FISH analysis reveals X mosaicism with no Y chromosome (X probe: red; Y probe: green).

Figure 4 Intraoperative pictures. (A) Left ovarian mass; (B) Mass with uterus and right adnexa; (C) Ileum dilatation due to mass compression; (D) Mass after it was takien out, with estimated size of 20 x 15 x 15 cm, showing the uterus, right adnexa, peritoneal sampling, and omental sampling.

Table 1 Literature Review of 46XX Karyotype Patients with Germ Cell Malignancy

Author	Year	Age	Karyotyping	Location	Staging*	Management	Pathology	Adjuvant
Erhan et al^Citation5	1992	26	46XX	Right	1A	TAH + BSO	Dysgerminoma	BEP
Obata et al^Citation3	1995	10	46XX	Bilateral	1B	Bilateral oophorectomy	Left dysgerminoma, right yolk sac tumour	BEP
Zhao et al^Citation4	2000	27	46XX	Right	1C2	Complete surgical staging	Mixed germ cell tumor	BEP
Erdemoglu et al^Citation6	2007	19	46XX	Unilateral	1A	Oophorectomy	Endodermal sinus tumor and gonodoblastoma	-
Gorosito et al^Citation8	2010	17	46XX	Left	1A	LSO followed by TAH + RSO	Dysgerminoma	BEP
Raafey et al^Citation7	2020	10	46XX	Left	1A	Conservative surgical staging	Gonadoblastoma with dysgerminoma	BEP 2 cycles then loss of follow up
Chandrapattan et al^Citation17	2022	9	46,XX	Right	1A	Conservative surgical staging	Gonadoblastoma with Dysgerminoma	BEP
Maidarti et al^Citation29	2023	16	Not tested	Right	2A	RSO	Dysgerminoma	BEP

Notes: *Staging based on case report description and staged with 2021 FIGO staging classification for cancer of the ovary, fallopian tube, and peritoneum.

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