Differential Analysis of Pregnancy Outcomes After Treatment of HIFU and LEEP in Patients with Cervical High-Grade Squamous Intraepithelial Lesions

Figures & data

Figure 1 Type of transformation zone (TZ). (A) Type 1. (B) Type 2. (C) Type 3.

Figure 2 Flowchart of patients included in the study.

Note: defined as weight in kilograms divided by the square of height in meters (kg/m2).

Abbreviations: HSIL, high-grade squamous intraepithelial lesion; TZ, transformation zone; ECC, endocervical curettage; LEEP, loop electrosurgical excision procedure; HIFU, High-Intensity Focused Ultrasound; BMI, body mass index.

Table 1 Baseline Clinical Features and Univariate Correlation Analysis

Categories	LEEP(n=46)			HIFU(n=46)			P-value
	n	%	Mean±SD/Median(IQR)	n	%	Mean±SD/Median(IQR)
Age(years)			30.54±3.59			29.09±3.64	0.559
CIN grade							0.145
CIN II	36	78.26		42	91.30
CIN III	10	21.74		4	8.70
Height(cm)			160.33±4.20			161.17±5.52	0.093
Pre-pregnancy weight			52.65±6.04			51.43±6.15	0.984
Weight gain during pregnancy			13.93±5.17			14.41±4.50	0.510
BMI predelivery(kg/m2)			25.93±2.09			25.38±2.40	0.137
Interval(month)*			31.00±15.85			25.20±11.52	0.222
Gravidity			1.50(2.00)			1.00(2.00)	0.088
Parity			1.00(1.00)			0.00(1.00)	0.003
0	18	39.13		33	71.74		<0.001
1	20	43.48		13	28.26
2	8	17.39		0	0.00
Preterm or not							0.242
Yes	3	6.52		0	0.00
Not	43	93.48		46	100.00
PROM or not							0.592
Yes	7	15.22		10	21.74
Not	39	84.78		36	78.26

Notes: defined as weight in kilograms divided by the square of height in meters(kg/m2); PROM: premature rupture of membrane. *Interval from post-treatment to delivery.

Abbreviations: LEEP, loop electrosurgical excision procedure; HIFU, High-Intensity Focused Ultrasound; SD, standard deviation; IQR, interquartile range; CIN, cervical squamous intraepithelial lesion; cm, centimeter; BMI, body mass index.

Table 2 Multivariate Logistic Analysis of the Differences in Preterm Outcome (P = 0.070)

Variate	Age	CIN Grade	Height	Pre-Pregnancy Weight	Weight Gain	BMI Predelivery	Interval*	Gravidity	Parity
P-value	0.284	0.615	0.113	0.614	0.135	0.067	0.879	0.061	0.263

Notes: defined as weight in kilograms divided by the square of height in meters(kg/m2). *Interval from post-treatment to delivery.

Abbreviations: CIN, cervical squamous intraepithelial lesion; BMI, body mass index.

Table 3 Multivariate Logistic Analysis of the Differences in PROM Outcome (P = 0.179)

Variate	Age	CIN Grade	Height	Pre-Pregnancy Weight	Weight Gain	BMI Predelivery	Interval*	Gravidity	Parity
P-value	0.431	0.634	0.098	0.556	0.781	0.151	0.094	0.332	0.399

Notes: defined as weight in kilograms divided by the square of height in meters(kg/m2). *Interval from post-treatment to delivery.

Abbreviations: PROM, premature rupture of membrane; CIN, cervical squamous intraepithelial lesion; BMI, body mass index.