Random-start GnRH antagonist for emergency fertility preservation: a self-controlled trial

Figures & data

Figure 1 Random-start GnRH antagonist protocols in the midfollicular phase (protocol B) versus the early luteal phase (protocol C).

Abbreviations: E2, estradiol; GnRH, gonadotropin-releasing hormone; antag, antagonist; sc, subcutaneous; rFSH, recombinant follicle-stimulating hormone; COH, controlled ovarian hyperstimulation.

Figure 2 Flow chart of the study population.

Note: Each number represents the number of people in the category.

Table 1 Baseline characteristics of the participants included in the study

Variable	Total women (n=11)	Midfollicular phase (n=6)	Early luteal phase (n=5)
Age, years	25.8±3.7	25.6±3.8	26.0±4.0
BMI, kg/m^2	23.4±3.5	22.6±2.6	24.1±4.1
Serum FSH, mIU/mL	6.9±1.3	7.1±1.5	6.8±1.3
AFC	11.5±2.6	12.8±3.6	10.6±1.4

Note: Values are expressed as the mean ± standard deviation.

Abbreviations: n, number; BMI, body mass index; FSH, follicle-stimulating hormone; AFC, antral follicle count.

Table 2 Within-group comparisons for both COH protocols with ganirelix

Variables	Standard COH (protocol A)	Midfollicular phase (protocol B)	P-value	Standard COH (protocol A)	Early luteal phase (protocol C)	P-value
Total women	6	6		5	5
Total number of oocytes	24.8±13.0	19.2±11.1	0.141	17.0±7.9	18.4±10.6	0.892
Mature oocytes (metaphase 2)	16.2±4.1	13.0±9.1	0.225	12.4±5.2	13.2±5.2	0.786
Immature oocytes	8.6±10.6	6.2±8.5	0.066	4.6±4.6	5.2±5.5	0.686
Fertilization rate	76.3%	75.9%	0.268	75.8%	78.1%	0.573
Top-quality embryos	45.4%	46.2%	0.451	47.1%	46.5%	0.853
Frozen embryos	4.3±2.8	4.1±2.1	0.278	3.9±1.9	4.6±2.3	0.342
Total rFSH dose, mIU/mL	1,680±445	1,595±300	0.500	1,966.7±559	1,837.5±580	0.753
Days on ganirelix	5.8±1.9	7.8±3.3	0.180	6.5±0.6	8.2±3.5	0.581
Days of stimulation	10.4±1.5	9.8±0.8	0.257	12.2±1.9	10.6±2.1	0.221
Clinical pregnancy rate, n (%)	3 (50)	6 (100)		2 (40)	3 (60)
Ongoing pregnancy rate, n (%)	3 (50)	5 (83.3)		2 (40)	2 (40)

Note: Data are expressed as the mean ± standard deviation unless otherwise stated.

Abbreviations: COH, controlled ovarian hyperstimulation; rFSH, recombinant follicle-stimulating hormone; n, number.