History of cardiovascular events and cardiovascular risk factors among patients initiating strontium ranelate for treatment of osteoporosis

Figures & data

Figure 1 Patient selection.

Table 1 Patient characteristicsa

Characteristic	Total (N=7,474)
Age, years (mean, SD)	76.5 (10.3)
Age, years
50–59	491 (6.6)
60–69	1,485 (19.9)
70–79	2,251 (30.1)
≥80	3,247 (43.4)
Sex
Male	714 (9.6)
Female	6,760 (90.4)
Index year
2008	1,777 (23.8)
2009	1,465 (19.6)
2010	1,273 (17.0)
2011	1,245 (16.7)
2012	1,124 (15.0)
2013	590 (7.9)
Comorbiditiesb
Hyperparathyroidism	12 (0.2)
Hypothyroidism	68 (0.9)
Hyperthyroidism	16 (0.2)
Chronic inflammatory bowel disease	2 (0.0)
Celiac disease	8 (0.1)
Vitamin D deficiency	30 (0.4)
Depression/anxiety	132 (1.8)
Alzheimer’s disease	35 (0.5)
Parkinson’s disease	28 (0.4)
History of OP-related eventsc
Diagnosis of OP	4,749 (63.5)
OP medication use
Bisphosphonate use	5,414 (72.4)
≥2 different bisphosphonates	2,030 (27.2)
Non-bisphosphonate use	3,195 (42.7)
None	1,155 (15.5)
OP-related fracture, past 12 months	1,324 (17.7)
Hip	719 (9.6)
Vertebral	133 (1.8)
Nonhip, nonvertebral	548 (7.3)

Notes:

a Values are presented as N (%) unless otherwise indicated;

b based on diagnostic codes occurring within the past 12 months;

c categories of osteoporosis medication use and osteoporosis-related fractures were not mutually exclusive.

Abbreviations: OP, osteoporosis; SD, standard deviation.

Table 2 History of cardiovascular eventsa

Cardiovascular event	Total (N=7,474)	Men (N=714)	Women (N=6,760)	P-valueb
Any event	1,767 (23.6)	252 (35.3)	1,515 (22.4)	<0.01*
Ischemic heart disease	977 (13.1)	147 (20.6)	830 (12.3)	<0.01*
Angina	792 (10.6)	118 (16.5)	674 (10.0)	<0.01*
Myocardial infarction	380 (5.1)	76 (10.6)	304 (4.5)	<0.01*
Cerebrovascular diseases	623 (8.3)	88 (12.3)	535 (7.9)	<0.01*
Stroke	595 (8.0)	82 (11.5)	513 (7.6)	<0.01*
Cerebral infarction	50 (0.7)	10 (1.4)	40 (0.6)	0.01*
Uncontrolled hypertension	244 (3.3)	27 (3.8)	217 (3.2)	0.41
Peripheral artery disease	157 (2.1)	32 (4.5)	125 (1.8)	<0.01*

Notes: Event categories are nonmutually exclusive.

a Values are presented as N (%);

b P-values are for the comparison between men and women;

* indicates statistical significance.

Table 3 Presence of cardiovascular risk factorsa

Risk factor	Total (N=7,474)	Men (N=714)	Women (N=6,760)	P-valueb
Any risk factor	3,431 (45.9)	309 (43.3)	3,122 (46.2)	0.14
Hypertension	2,880 (38.5)	272 (38.1)	2,608 (38.6)	0.80
Hyperlipidemia	1,392 (18.6)	113 (15.8)	1,279 (18.9)	0.04*
Obesity	624 (8.3)	40 (5.6)	584 (8.6)	<0.01*
Type 2 diabetes	351 (4.7)	40 (5.6)	311 (4.6)	0.23

Notes: Cardiovascular risk was tabulated only for patients without a history of cardiovascular events. Risk categories are nonmutually exclusive.

a Values are presented as N (%);

b P-values are for the comparison between men and women,

* indicates statistical significance.