Profile of follitropin alpha/lutropin alpha combination for the stimulation of follicular development in women with severe luteinizing hormone and follicle-stimulating hormone deficiency

Figures & data

Table 1 Use of rFSH and rLH to restore fertility in HH women: ovulation and pregnancy in relation to the rLH doses

Dose of rLH, IU	0	25	75/225
Number of patients with adequate ovulation induction, n/N	0/11	6/12	16/26
Number of pregnant patients, n	0	0	6

Note: Data from The European Recombinant Human LH Study Group⁶³ and O’Dea et al.⁶⁸

Abbreviations: HH, hypogonadotropic hypogonadism; rFSH, recombinant follicle-stimulating hormone; rLH, recombinant luteinizing hormone.

Table 2 Clinical results with the use of rFSH and rLH in HH women

Study	Type of study	Number of patients	Number of cycles	Number of pregnancies	PR per patient (%)	PR per cycle (%)	PR per hCG (%)
Kousta et al^Citation58	Case report	1	2	1	100	50	50
Agrawal et al^Citation10	Case report	1	3	1	100	33	33
Campo et al^Citation60	Case report	1	1	1	100	100	100
European Recombinant Human LH Study Group,^Citation63	Prospective, randomized	38	53	–	–	20.29	–
Burgués et al^Citation65	Prospective, randomized	38	84	15	39.5	18	22
El-Shawarby et al^Citation61	Case report	1	2	1	100	50	50
Balasch and Fábregues^Citation62	Case report	1	1	1	100	100	100
Kaufmann et al^Citation66	Prospective, randomized	31	54	20	64	37	59.3
Shoham et al^Citation67	Prospective, randomized	27	27	2	8	8	15
O’Dea et al^Citation68	Prospective, randomized	15	–	3	20	–	–
Carone et al^Citation69	Prospective, randomized	17	27	15	88.2	55.5	–

Abbreviations: hCG, human chorionic gonadotropin; HH, hypogonadotropic hypogonadism; PR, pregnancy rate; rFSH, recombinant follicle-stimulating hormone; rLH, recombinant luteinizing hormone.

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