Serum total IgG and IgG4 levels in thyroid eye disease

Figures & data

Table 1 Serum total IgG, IgG subclass, and TSI in TED patients

Case	Age (years)	Gender	Total IgG (mg/dL)	IgG1 (mg/dL)	IgG2 (mg/dL)	IgG3 (mg/dL)	IgG4 (mg/dL)	IgG4:IgG ratio	TSI (%)
1	55	F	1,496	760	558	94	167	0.112	753
2	39	M	1,202	542	584	105	106.3	0.088	353
3	53	F	1,294	649	572	80	123	0.095	323
4	57	F	987	556	250	19	97	0.098	354
5	60	M	832	409	400	76	64	0.077	393
6	53	F	N/A	323	202	36	31	N/A	516
7	35	M	N/A	708	295	31	26	N/A	353
8	64	F	N/A	845	438	102	55	N/A	287
9	47	F	951	439	504	362	32.5	0.034	599
10	32	M	N/A	359	469	59	17	N/A	377
11	33	F	1,545	815	715	76	55.2	0.036	<89a
12	73	F	1,546	974	380	52	32.6	0.021	446
13	40	F	1,066	535	390	57	61	0.057	250
14	68	F	829	318	494	62	59	0.071	24b
15	42	F	1,241	791	343	81	61	0.049	683
16	51	F	746	433	269	25	4.5	0.006	472
17	70	F	499	364	102	6	3.8	0.008	<89c
18	36	M	1,033	452	460	77	38.2	0.037	569
19	57	F	972	565	220	63	7	0.007	579
20	74	F	1,191	676	296	184	90.4	0.076	474
21	50	F	983	611	286	43	60	0.061	257
22	32	F	1,335	469	863	67	153	0.115	539
23	22	F	1,314	813	344	78	66.4	0.051	401
24	62	F	1,272	668	420	58	20.7	0.016	<89d
	Mean (median)	M:F ratio	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)	N/A	Mean (SD)
	50.2 (52)	0.26:1	1,116.7 (277.0)	586.4 (184.6)	410.6 (170.8)	78.9 (70.0)	59.7 (44.2)	N/A	386.2 (191.8)

Notes:

a Patient with elevated thyroid peroxidase antibody and thyroglobulin antibody consistent with Hashimoto’s thyroiditis.

b Patient with TSI 178% 1 year prior, with enlarged right inferior rectus on MRI.

c Patient with TSI 339% 6 months prior, with enlarged right inferior and medial recti on MRI.

d Patient with a 2-year history of TED prior to consultation.

Abbreviations: F, female; M, male; MRI, magnetic resonance imaging; N/A, not available; SD, standard deviation; TED, thyroid eye disease; TSI, thyroid stimulating immunoglobulin; IgG, immunoglobulin G.