Paracetamol and analgesic nephropathy: Are you kidneying me?

Figures & data

Table 1 Mrs MJ’s medication profile

Medication	Dose and frequency
Amlodipine 5 mg	One tablet daily
Irbesartan 300 mg	One tablet daily
Sotalol 80 mg	Half a tablet twice daily
Moxonidine 200 μg	One tablet daily
Simvastatin 40 mg	One tablet at night
Dabigatran 150 mg	One tablet twice a day
Calcium 600 mg	One tablet daily
Thyroxine 50 μg	One tablet daily
Pantoprazole 40 mg	One tablet when required (usually once a week)
Paracetamol SR 665 mg	Not using (prescribed one tablet three times a day)
Paracetamol 500 mg/codeine 30 mg	One tablet at night
Folic acid 0.5 mg	One tablet daily
Vitamin B6 240 mg	One tablet daily
Vitamin B12 100 μg	One tablet daily

Figure 1 Metabolism of phenacetin to paracetamol and further metabolites.

Figure 2 Incidence of analgesic nephropathy (AN) in patients admitted for renal replacement therapy in New South Wales (NSW), Australia and Flanders, Belgium.

Note: Republished with permission of J Am Soc Nephrol from Trends of analgesic nephropathy in two high-endemic regions with different legislation, Michielsen P, De Schepper P, 12(3):550–556, 2001; permission conveyed through Copyright Clearance Center, Inc.²⁶

MichielsenPDe SchepperPTrends of analgesic nephropathy in two high-endemic regions with different legislationJ Am Soc Nephrol200112355055611181803

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