Sacrococcygeal teratoma in a female newborn with clinical features of trisomy 13: a case report from Central Africa

Figures & data

Figure 1 Craniofacial abnormalities observed in our patient.

Note: Note capillary hemangioma, bilateral cleft, and palate.

Figure 2 Large sacrococcygeal teratoma.

Table 1 Clinical features in trisomy 13 with molecular confirmation versus our patient

	Studies
	Patau et al^Citation7 (Publication princeps)	Lin et al^Citation8	Petry et al^Citation9	Quelin et al^Citation10	Mbuyi-Musanzayi et al^Citation11	Patient
Year	1960	2007	2013	2014	2014	2014
Country	USA	Taiwan	Brazil	France	Democratic Republic of Congo	Democratic Republic of Congo
Samples (N)	1	28	30	3	1	1
Features	%	%	%	%	%	%
Craniofacial
Abnormal auricles	+	?	77	0	−	−
Microphthalmia	−	54	60	33	+	−
Anophthalmia	+	?	?	33	−	+
Low-set ears	?	?	47	33	+	+
Aplasia cutis/scalp defect	−	29	43	0	−	−
Microcephaly	−	61	40	0	+	+
Cleft palate	+	?	33	0	+	+
Cleft lip	+	?	23	0	+	+
Short neck	?	46	30	0	+	+
Ocular hypotelorism	+	?	10	0	+	+
Thorax/abdomen
Inguinal hernia/umbilical hernia	?	14	20	0	+	−
Anogenital
Cryptorchidism	−	73	78	0	+	−
Micropenis	−	?	30	0	+	−
Postaxial polydactyly hands/feet	+	64	63	0	+	−
Single palmar crease	?	32	33	0	−	−
Duplicated hallux		?	3	33	−	−
Capillary hemangioma	?	14	27	0	+	+
Mongolian spot	?	?	NA	0	+	−
Hypertonia/hypotonia	?	?	33	0	+	+

Abbreviations: NA, not applicable; ?, data not available.

Table 2 Overview of reported teratoma in patients with chromosomal disorder syndromes

Chromosomal disorder	Localization	Study	Year
Trisomy 13	Liver and neck	Dische and Gardner^Citation13	1978
Trisomy 12	Ovarian	López Ginés et al^Citation20	1989
Trisomy 1q and 19p	Facial	Schwartz et al^Citation21	1992
Trisomy 13	Oral	Yapar et al^Citation14	1995
Trisomy 3	Ovarian	Mertens et al^Citation22	1998
Tetrasomy 1q	Oral	Scheres et al^Citation27	1999
Trisomy 1q	Sacrococcygeal	Wax et al^Citation17	2000
Monosomy 7q/trisomy 2p	Sacrococcygeal	Le caignec et al^Citation23	2003
Trisomy 13	Umbilical cord	Hargitai et al^Citation15	2005
Trisomy 10q/monosomy 17p	Sacrococcygeal	Batukan et al^Citation24	2007
Trisomy 3q	Sacrococcygeal	Dundar et al^Citation18	2011

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