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Case Report

Synergistic effect of regenerating agent plus cord blood serum eye drops for the treatment of resistant neurotrophic keratitis: a case report and a hypothesis for pathophysiologic mechanism

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Pages 277-281 | Published online: 02 Nov 2015

Figures & data

Figure 1 Corneal graft melting.

Note: Corneal graft melting observed when patient came to the emergency ward.
Figure 1 Corneal graft melting.

Figure 2 Corneal graft perforation with iris prolapse.

Note: Corneal graft melting rapidly progressed to corneal perforation with iris prolapse although given the systemic and topic broad-spectrum antibiotic therapy.
Figure 2 Corneal graft perforation with iris prolapse.

Figure 3 Corneal ulcer before study treatment.

Note: Corneal ulcer affected epithelium, Bowman membrane, and anterior stroma with a longest linear diameter equal to 7 mm and a greatest perpendicular width equal to 5 mm.
Figure 3 Corneal ulcer before study treatment.

Figure 4 Confocal microscopy analysis of corneal ulcer before study treatment.

Note: Confocal microscopy analysis showed no nerve regeneration and stromal inflammation in corneal graft.
Figure 4 Confocal microscopy analysis of corneal ulcer before study treatment.

Figure 5 Corneal ulcer after 2 weeks of study treatment (V2).

Note: Corneal ulcer improved after therapy with a partial healing >50% already in V2.
Figure 5 Corneal ulcer after 2 weeks of study treatment (V2).

Figure 6 Corneal ulcer healing after 4 weeks of study treatment (V4).

Note: Corneal ulcer completely healed in V4.
Figure 6 Corneal ulcer healing after 4 weeks of study treatment (V4).

Figure 7 Confocal microscopy analysis of the cornea after 4 weeks of study treatment (V4).

Note: Confocal miscroscopy showed complete resolution of stromal inflammation in V4.
Figure 7 Confocal microscopy analysis of the cornea after 4 weeks of study treatment (V4).