Targeting CD22 for the Treatment of B-Cell Malignancies

Figures & data

Figure 1 Legend: Simplified schema depicting current therapies targeting CD22 in B-cell malignancies. (A) Naked antibody; (B) Antibody-drug conjugate; (C) Radioimmunoconjugate; (D) Bispecific antibody/bispecific T-cell engager; (E) Chimeric antigen receptor (CAR)-T cell; (F) Bispecific CAR-T cell; (G) Tandem bispecific CAR-T cell. Abbreviations: ⁹⁰Y, Yttrium-90. Figure created with BioRender.com.

Table 1 Selected Ongoing Studies Investigating CD22 Targeted Therapies in B-Cell Malignancies

Title	Trial Number	Status	Phases
S1312, Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Leukemia	NCT01925131	Active, not recruiting	Phase 1
Inotuzumab Ozogamicin for Children With MRD Positive CD22+ Lymphoblastic Leukemia	NCT03913559	Recruiting	Phase 2
Study of Inotuzumab Ozogamicin Combined to Chemotherapy in Older Patients With Philadelphia Chromosome-negative CD22+ B-cell Precursor ALL	NCT03249870	Recruiting	Phase 2
Study of Anti-CD22 CAR-T Cells Treating Leukemia Children	NCT04340167	Recruiting	Phase 2
Study of Sequential CAR-T Cell Treating Leukemia Children	NCT04340154	Recruiting	Phase 2
Inotuzumab Ozogamicin and Chemotherapy in Treating Patients With Leukemia or Lymphoma Undergoing Stem Cell Transplantation	NCT03856216	Recruiting	Phase 2
Inotuzumab Ozogamicin in Treating Patients With B-cell Acute Lymphocytic Leukemia With Positive Minimal Residual Disease	NCT03441061	Recruiting	Phase 2
Targeting CD19 and CD22 CAR-T Cells Immunotherapy in Patients With Relapsed or Refractory Acute B Lymphocytic Leukemia	NCT04714593	Recruiting	Phase 1|Phase 2
CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies	NCT03448393	Recruiting	Phase 1
Adult B-ALL Treated by CART Cell Bridging Allogeneic Hematopoietic Stem Cell Transplantation	NCT04626726	Recruiting	Early Phase 1
Inotuzumab Ozogamicin and Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia	NCT03851081	Recruiting	Phase 1|Phase 2
Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia	NCT03150693	Recruiting	Phase 3
Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Acute Lymphoblastic Leukemia	NCT01371630	Recruiting	Phase 1|Phase 2
Phase I/II Study of Bosutinib in Combination With Inotuzumab Ozogamicin in CD22-positive PC Positive ALL and CML	NCT02311998	Recruiting	Phase 1|Phase 2
Inotuzumab Ozogamicin and Blinatumomab in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia	NCT03739814	Recruiting	Phase 2
Blinatumomab, Inotuzumab Ozogamicin, and Combination Chemotherapy as Frontline Therapy in Treating Patients With B Acute Lymphoblastic Leukemia	NCT02877303	Recruiting	Phase 2
CD19/CD22 Chimeric Antigen Receptor(CAR) T Cells in Adults With Recurrent/Refractory B Cell Malignancies	NCT03233854	Recruiting	Phase 1
Phase I Dose Escalation Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory B Cell Malignancies	NCT03241940	Recruiting	Phase 1
A Feasibility and Safety Study of Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cell Immunotherapy for Relapsed or Refractory Leukemia and Lymphoma	NCT03398967	Recruiting	Phase 1|Phase 2
CD22 Redirected Autologous T Cells for ALL	NCT02650414	Recruiting	Phase 1
A Clinical Research of CD19 and CD22 Targeted Prime CAR-T Cell in Relapsed/Refractory B Cell Lymphoma	NCT04782193	Active, not recruiting	Phase 1|Phase 2
Multi-CAR-T Cells Targeting B Cell Lymphomas	NCT04429438	Recruiting	Phase 1|Phase 2
Anti-CD22 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy for Relapsed Refractory B-cell Malignancies	NCT04007978	Recruiting	Phase 1
CD22-CAR T Cells in Children and Young Adults With B Cell Malignancies	NCT04088864	Recruiting	Phase 1
Safety and Efficacy of ThisCART22 in Patients With Refractory or Relapsed B Cell Malignancies	NCT04601181	Recruiting	Phase 1
Safety and Efficacy Study of CD22 CAR-T Cells for Relapsed or Refractory Acute Lymphoblastic Leukemia	NCT04546906	Recruiting	Not Applicable
A Clinical Research of CD19 and CD22 Targeted Prime CAR-T Cell in Relapsed/Refractory B-ALL	NCT04781634	Active, not recruiting	Phase 1|Phase 2
Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B-ALL	NCT04499573	Recruiting	Phase 1|Phase 2
Autologous CD22 CAR T Cells in Adults w/ Recurrent or Refractory B Cell Malignancies	NCT04088890	Recruiting	Phase 1
Phase I Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)	NCT04150497	Recruiting	Phase 1
A Study of GC022F CAR-T Cell Immunotherapy for Relapsed or Refractory B- ALL	NCT04129099	Recruiting	Early Phase 1
Sequential CD19 and CD22 CAR-T Therapy for Newly Diagnosed Ph+ B-ALL	NCT04788472	Recruiting	Phase 1|Phase 2
Sequential CD19 and CD22 CAR-T Therapy for Newly Diagnosed Ph- B-ALL	NCT04740203	Recruiting	Phase 1|Phase 2
CAR-T Immunotherapy Targeting CD19- ALL	NCT04016129	Recruiting	Phase 1|Phase 2
CD19 and CD22 Dual-targeted CAR-T Cells for Relapsed or Refractory B-NHL	NCT04303247	Not yet recruiting	Early Phase 1
Combination CAR-T Cell Therapy Targeting Hematological Malignancies	NCT03125577	Recruiting	Phase 1|Phase 2
A Study of GC022F CAR-T Cell Immunotherapy for Relapsed or Refractory B- NHL	NCT04412174	Not yet recruiting	Early Phase 1
ADCT-602 in Treating Patients With Recurrent or Refractory B-cell Acute Lymphoblastic Leukemia	NCT03698552	Recruiting	Phase 1|Phase 2
4SCAR-T Therapy Post CD19-targeted Immunotherapy	NCT04430530	Recruiting	Phase 1|Phase 2
Modified Immune Cells (CD19-CD22 CAR T Cells) in Treating Patients With Recurrent or Refractory CD19 Positive, CD22 Positive Leukemia or Lymphoma	NCT04029038	Not yet recruiting	Phase 1|Phase 2
Anti-CD19/CD22 Bispecific CAR-T Cell Therapy for CD19-positive ALL	NCT04303520	Recruiting	Phase 1
CART22 Alone or in Combination With huCART19 for ALL	NCT03620058	Active, not recruiting	Phase 1
CAR-T for Children With Relapsed and Refractory Acute Lymphoblastic Leukemia	NCT04626765	Recruiting	Early Phase 1
Inotuzumab Ozogamicin Post-Transplant For Acute Lymphocytic Leukemia	NCT03104491	Recruiting	Phase 1|Phase 2
A Clinical Research of CD22-Targeted CAR-T in B Cell Malignancies	NCT03999697	Recruiting	Phase 1
CD19/22 CAR T Cells (AUTO3) for the Treatment of Diffuse Large B Cell Lymphoma	NCT03287817	Recruiting	Phase 1|Phase 2
Dual Target CAR-T Cells in B-cell Acute Lymphoblastic Leukemia	NCT04723901	Recruiting	Phase 1|Phase 2
Anti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults With Recurrent or Refractory CD22-expressing B Cell Malignancies	NCT02315612	Recruiting	Phase 1
Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients With Relapsed/Refractory Hairy Cell Leukemia and Variant	NCT04815356	Not yet recruiting	Phase 1
CMC-544 and Allogeneic Transplantation for CD22 Positive-Lymphoid Malignancies	NCT01664910	Active, not recruiting	Phase 1|Phase 2
A Phase 1 Study of CD22-CAR TCell Immunotherapy for CD22+ Leukemia and Lymphoma	NCT03244306	Active, not recruiting	Phase 1
A Treatment Study Protocol for Participants 1-45 Years With Acute Lymphoblastic Leukaemia	NCT04307576	Recruiting	Phase 3
Safety and Efficacy of CD19 and CD22 Targeted CAR-T Therapy for Relapsed/Refractory B Cell Leukemia and Lymphoma	NCT04648475	Recruiting	Phase 1|Phase 2
CD19 and CD22 Targeted CAR-T Cell Therapy for Relapsed/Refractory B Cell Leukemia and Lymphoma	NCT04649983	Recruiting	Phase 1|Phase 2
Anti-CD22 CAR-T Cell Therapy Targeting B Cell Malignancies	NCT03262298	Recruiting	Phase 1|Phase 2
A Clinical Research of CD22-Targeted CAR-T in B Cell Malignancies	NCT02935153	Recruiting	Phase 1|Phase 2
Immunotherapy With CD22 CAR T-cells for B-Cell Lymphoma, ALL and CLL	NCT04163575	Not yet recruiting	Phase 1|Phase 2
A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia	NCT03330691	Recruiting	Phase 1
A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD22 for Relapsed/Refractory Leukemia or Lymphoma	NCT04571138	Recruiting	Phase 1|Phase 2
Leukapheresis for CAR or Adoptive Cell Therapy Manufacturing	NCT03226704	Recruiting
A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients	NCT03677596	Recruiting	Phase 4
Targeting CD19 and CD22 CAR-T Cells Immunotherapy in Patients With Relapsed or Refractory B Cell Lymphoma	NCT04715217	Recruiting	Phase 1|Phase 2
A Single-center Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of LCAR-L10D Cell Formulations Targeting CD19 and CD22 in Patients With CD19- and/or CD22-Positive Relapsed/Refractory B-cell Lymphoma	NCT03593109	Recruiting	Phase 1
A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)	NCT04540796	Recruiting	Phase 1
Study of TRPH-222 in Patients With Relapsed and/or Refractory B-Cell Lymphoma	NCT03682796	Recruiting	Phase 1
Anti-CD19/CD22 Bispecific CAR-T Cell Therapy for MRD Positive ALL	NCT03919526	Recruiting	Phase 1
Targeting CD19 and BCMA CAR-T Cells Immunotherapy in Patients With Relapsed or Refractory Multiple Myeloma	NCT04714827	Recruiting	Phase 1|Phase 2
Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia	NCT02981628	Recruiting	Phase 2
Inotuzumab Ozogamicin and Chemotherapy in Treating Patients With Recurrent or Refractory B-cell Acute Lymphoblastic Leukemia	NCT03991884	Recruiting	Phase 1
CD19/CD22-Dual-STAR-T for Patients With B Cell Acute Leukemia(B-ALL)	NCT04508842	Not yet recruiting	Phase 1
Study of Anti-CD22 CAR NK Cells in Relapsed and Refractory B Cell Lymphoma	NCT03692767	Not yet recruiting	Early Phase 1
CAR-T Cells in Treating Patients With Relapsed or Refractory NHL	NCT04626739	Recruiting	Early Phase 1
Anti-CD19 Allo-CAR-T Cells for Relapsed B Cell Malignancies After HSCT	NCT04516551	Recruiting	Phase 1
A Study of CD20/CD22 Targeted CAR T-cell Therapy for Relapsed or Refractory Lymphoid Malignancies	NCT04283006	Recruiting	Early Phase 1
Clinical Study of Targeting CD19 and CD22 Chimeric Antigen Receptor T Lymphocytes in the Treatment of Recurrent or Refractory B Cell Non-Hodgkin Lymphoma	NCT04626908	Not yet recruiting	Phase 1|Phase 2
A Clinical Study of CAR-T Cells Treatment for Children With CD19+/CD22+ R/R ALL and Lymphoma	NCT04204161	Recruiting	Phase 1
CAR-T for R/R B-NHL	NCT03196830	Recruiting	Phase 2
CD19-CD22 Chimeric Antigen Receptor T (CAR-T) Cell for Treatment of B Cell Acute Lymphoblastic Leukemia (B-ALL)	NCT04034446	Active, not recruiting	Early Phase 1
An Early Access Programme for Moxetumomab Pasudotox in Relapsed/Refractory Hairy Cell Leukemia	NCT03501615	Approved for marketing

Notes: Data from clinicaltrials.gov (Accessed May 11, 2021).