Dendritic cell vaccination for glioblastoma multiforme: review with focus on predictive factors for treatment response

Figures & data

Table 1 EORTC RPA classification for newly diagnosed GBM

RPA class	Age (years)	WHO performance scale	MMSE	Surgery
3	<50	0
4	<50	1–2
	≥50		≥27	Complete/partial
5	≥50		<27
	or ≥50			Biopsy only

Note: Reprinted with permission. © 2006 American Society of Clinical Oncology. All rights reserved. Mirimanoff R-O, et al. J Clin Oncol. 24(16), 2006:2563–2569.⁶⁸

Abbreviations: EORTC, European Organization for Research and Treatment of Cancer; GBM, glioblastoma multiforme; MMSE, Mini-Mental State Examination; RPA, recursive partitioning analysis; WHO, World Health Organization.

Figure 1 HGG immuno RPA classification for relapsed HGG.

Note: Reprinted from De Vleeschouwer S, et al. Stratification according to HGG-IMMUNO RPA model predicts outcome in a large group of patients with relapsed malignant glioma treated by adjuvant postoperative dendritic cell vaccination. Cancer Immunol Immunother. 2012;61(11):2105–2112.⁴⁶ With kind permission from Springer Science and Business Media.
Abbreviations: HGG, high-grade glioma; RPA, recursive partitioning analysis; WHO, world health organization; KPS, Karnofsky Performance Score; MMSE, Mini-Mental State Examination.

Table 2 Multiscale parameters possibly predicting outcome after DC vaccination

• Patient history and comorbidity

•RPA classification

• Extent of resection

• Tumor characteristics: genetics, transcriptomes, histology, and immunohistochemistry

• Other oncologic treatment: radiotherapy, chemotherapy

• Timing of treatment

• Dendritic cells: number, purity, viability

• Serial MRI during treatment

• Peripheral immune monitoring during treatment

Abbreviations: DC, dendritic cells; MRI, magnetic resonance imaging; RPA, recursive partitioning analysis.

MirimanoffR-OGorliaTMasonWRadiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trialJ Clin Oncol200624162563256916735709

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De VleeschouwerSArdonHVan CalenberghFStratification according to HGG-IMMUNO RPA model predicts outcome in a large group of patients with relapsed malignant glioma treated by adjuvant postoperative dendritic cell vaccinationCancer Immunol Immunother201261112105211222565485

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