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Original Research

Control of moderate-to-severe asthma with randomized ciclesonide doses of 160, 320 and 640 μg/day

, , , &
Pages 35-46 | Published online: 07 Mar 2017

Figures & data

Table 1 ICS pretreatment dose and ACQ at the start of baseline

Figure 1 Summary of all patients who were enrolled, randomized, completed and discontinued during the study.

Abbreviation: AE, adverse event.
Figure 1 Summary of all patients who were enrolled, randomized, completed and discontinued during the study.

Table 2 Baseline demographics in the ITT population

Table 3 Change from baseline to last visit in ACQ score of within-treatment and between-treatment differences with three Cic doses

Table 4 LS mean change from baseline to last visit in ACQ score of between-treatment differences with Cic 640, 320 and 160 μg/day by exacerbation history subgroups (ITT)

Figure 2 Kaplan–Meier plot of time from randomization to well-controlled asthma in the ITT population.

Abbreviations: Cic, ciclesonide; ITT, intention-to-treat.
Figure 2 Kaplan–Meier plot of time from randomization to well-controlled asthma in the ITT population.

Table 5 Analysis of well-controlled asthma parameters over 52 weeks of treatment

Table 6 Post hoc sensitivity analyses for change from baseline to last visit in FEV1 of between-treatment differences in the ITT population

Table S1 Additional baseline demographics in the ITT population

Table S2 Concomitant use of short-acting beta 2-agonists in the ITT population

Table S3 Subgroup analyses of change from baseline to last visit in ACQ score of between-treatment differences with Cic 640 μg/day and Cic 160 μg/day (ITT)

Table S4 AEs occurring in at least 5% of patients in any treatment group