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Original Research

Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma

Ken Junyang Goh1 Department of Respiratory and Critical Care Medicine, Singapore General Hospital

Anthony Chau Ang Yii1 Department of Respiratory and Critical Care Medicine, Singapore General Hospital;2 Duke-National University of Singapore Medical School

Therese Sophie Lapperre1 Department of Respiratory and Critical Care Medicine, Singapore General Hospital;2 Duke-National University of Singapore Medical School

Adrian KW Chan1 Department of Respiratory and Critical Care Medicine, Singapore General Hospital;2 Duke-National University of Singapore Medical School;3 Allergy Centre, Singapore General Hospital

Fook Tim Chew4 Department of Biological Sciences, Faculty of Science, National University of Singapore

Sanjay H Chotirmall5 Lee Kong Chian School of Medicine, Nanyang Technological University, SingaporeCorrespondence[email protected]

Mariko Siyue Koh1 Department of Respiratory and Critical Care Medicine, Singapore General Hospital;2 Duke-National University of Singapore Medical School;3 Allergy Centre, Singapore General Hospital

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Table 1 Characteristics of patients with severe asthma (N=206)

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Figure 1 Prevalence of allergen sensitization in patients with severe asthma in an Asian cohort (N=206).

Abbreviations: BT, Blomia tropicalis; Der F, Dermatophagoides farinae; Der P, Dermatophagoides pteronyssinus; SPT, skin prick test.

Table 2 Characteristics of patients with controlled and uncontrolled asthma, defined by one or more of the following: ≥2 steroid bursts in the past year, hospitalization in the past year, a history of near-fatal asthma or FEV₁ <80% predicted with FEV₁/FVC <0.7

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Table 3 Characteristics of patients with and without sensitization to Aspergillus

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Figure 2 Multivariate analyses of allergen sensitization associated with indicators of uncontrolled asthma.

Note: Age, gender, ethnicity, body mass index, smoking history (active or ex-smoker) and all other allergens were included in the multivariate analyses.
Abbreviations: CI, confidence intervals; OR, odds ratio.

Table 4 Multivariate analyses of Aspergillus sensitization associated with indicators of uncontrolled asthma

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Table 5 Characteristics of patients with severe asthma based on ethnicity

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Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma

Table 1 Characteristics of patients with severe asthma (N=206)

Table 2 Characteristics of patients with controlled and uncontrolled asthma, defined by one or more of the following: ≥2 steroid bursts in the past year, hospitalization in the past year, a history of near-fatal asthma or FEV₁ <80% predicted with FEV₁/FVC <0.7

Table 3 Characteristics of patients with and without sensitization to Aspergillus

Table 4 Multivariate analyses of Aspergillus sensitization associated with indicators of uncontrolled asthma

Table 5 Characteristics of patients with severe asthma based on ethnicity

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Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma

Figures & data

Table 1 Characteristics of patients with severe asthma (N=206)

Table 2 Characteristics of patients with controlled and uncontrolled asthma, defined by one or more of the following: ≥2 steroid bursts in the past year, hospitalization in the past year, a history of near-fatal asthma or FEV1 <80% predicted with FEV1/FVC <0.7

Table 3 Characteristics of patients with and without sensitization to Aspergillus

Table 4 Multivariate analyses of Aspergillus sensitization associated with indicators of uncontrolled asthma

Table 5 Characteristics of patients with severe asthma based on ethnicity

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Table 2 Characteristics of patients with controlled and uncontrolled asthma, defined by one or more of the following: ≥2 steroid bursts in the past year, hospitalization in the past year, a history of near-fatal asthma or FEV₁ <80% predicted with FEV₁/FVC <0.7