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Journal of Asthma and Allergy Volume 15, 2022 - Issue
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REVIEW

Further Understanding of Neuro-Immune Interactions in Allergy: Implications in Pathophysiology and Role in Disease Progression

George N Konstantinou1 Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, Thessaloniki, GreeceCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1371-6764
ORCID Icon,
Gerasimos N Konstantinou2 Department of Psychiatry, University of Toronto, Toronto, ON, Canada;3 Centre of Addiction and Mental Health (CAMH), Toronto, ON, CanadaORCID Iconhttps://orcid.org/0000-0002-0303-1633
ORCID Icon,
Christopher Koulias4 Allergy Unit, 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece
,
Konstantinos Petalas5 Department of Allergy, 251 General Air Force Hospital, Athens, Greece
&
Michael Makris4 Allergy Unit, 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, GreeceORCID Iconhttps://orcid.org/0000-0003-2713-2380
ORCID Icon
Pages 1273-1291 | Received 21 Jan 2022, Accepted 25 Aug 2022, Published online: 10 Sep 2022

Figures & data

Figure 1 The neuroimmunological inflammation in allergic rhinitis and chronic rhinosinusitis.

Abbreviations: NGF, nerve growth factor; BDNF, brain-derived neurotrophic factor; SP, substance P; CGRP, calcitonin gene-related peptide; CRTH2, chemoattractant receptor-homologous molecule expressed on T helper 2 (Th2) cells; CNS, central nervous system.
Figure 1 The neuroimmunological inflammation in allergic rhinitis and chronic rhinosinusitis.

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