Clinical Management of Infant Anaphylaxis

Figures & data

Figure 1 Review of unique aspects regarding management of infant anaphylaxis.

Figure 2 Treatment of infant anaphylaxis.

Note: Data from Simons et al.¹⁸

Table 1 Signs of Infant Anaphylaxis^4,18,26

Classic Symptoms	Non-Classic Symptoms
Skin: hives, rashes, itching, angioedema	Skin: eye rubbing, eye itching, ear scratching, tongue thrusting, tongue pulling, repetitive lip licking or licking of hands
GI: vomiting, diarrhea, abdominal pain	GI: spitting up, back arching, bringing knees to chest, hiccups
Respiratory: cough, wheeze, tachypnea	Respiratory: hoarse voice/cry, putting fingers in ears, ear pulling
CV: hypotension, fainting	CV: skin mottling
	Neuro: crankiness, inconsolable crying, withdrawn/clingy

Note: Data from Greenhawt et al ⁴, Simons  et al ¹⁸, Pistiner et al ²⁶.

Simons FE, Sampson HA. Anaphylaxis: unique aspects of clinical diagnosis and management in infants (birth to age 2 years). J Allergy Clin Immunol. 2015;135(5):1125–1131. doi:10.1016/j.jaci.2014.09.014

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Greenhawt M, Gupta RS, Meadows JA, et al. Guiding principles for the recognition, diagnosis, and management of infants with anaphylaxis: an expert panel consensus. J Allergy Clin Immunol Pract. 2019;7(4):1148–1156.e5. doi:10.1016/j.jaip.2018.10.052

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Pistiner M, Mendez-Reyes JE, Eftekhari S, et al. Caregiver-reported presentation of severe food-induced allergic reactions in infants and toddlers. J Allergy Clin Immunol Pract. 2021;9(1):311–320 e2. doi:10.1016/j.jaip.2020.11.005

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