Lipid Profile and IL-17A in Allergic Rhinitis: Correlation With Disease Severity and Quality of Life

Figures & data

Table 1 Demographic and Laboratory Data Characteristics of the Study Groups

Characteristics	Allergic Rhinitis group N=70	Healthy Control Group N=80	χ^2/t-Test	P-value
Gender, n (%)
Female	29 (41.4)	37 (46.2)	0.352	0.553
Male	41 (58.6)	43 (53.8)
Age, years
Mean ± SD	30.7 ± 7.2	32.9 ± 7.5	−1.475	0.083
Associated allergic diseases, n (%)
None	47 (67)	/	/	/
Allergic conjunctivitis	21 (30)	/	/	/
Atopic dermatitis	2 (3)
BMI (kg/m^2)
Mean ± SD	21.601 ± 2.395	22.003 ± 2.162	−1.082	0.281
Family history
Positive	40 (57.1)
Negative	30 (42.9)
VAS
Mild	2 (2.9)
Moderate	57 (81.4)
Severe	11 (15.7)
QOL
Mean ± SD	4.347 ± 0.942
Total IgE (IU/mL)
Median (range)	153 (12.5–531)	71.5 (10.9–329)	−4.325^#	<0.001**
IL-17A (pg/mL)
Mean ± SD	46.34 ± 7.76	28.88 ± 8.6	12.992	<0.001**

Notes: **p≤0.001 is statistically highly significant. χ², chi square test; t: Independent sample t-test. ^#Mann–Whitney test.

Abbreviations: VAS, visual analogue score; QOL, quality of life.

Table 2 Serum Lipid Profile of Study Subjects

Lipid Profile (mg/dL)	AR Group N=70	Control Group N=80	t-Test	P-value
TG Mean ± SD	136.34 ± 28.31	137.36± 15.73	−0.267	0.79
TC Mean ± SD	225.65± 62.91	187.92± 35.24	4.445	<0.001**
HDL-C Mean ± SD	47.25± 5.36	49.83± 4.29	−3.276	0.001^**
LDL-C Mean ± SD	151.57± 60.42	121.57 ± 19.03	3.999	<0.001
VLDL-C Mean ± SD	35.05± 11.19	34.46± 10.43	−1.363	0.175

Notes: **p≤0.001 is statistically highly significant. t: Independent sample t test.

Abbreviations: TG, triglycerides; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; VLDL-C, very-low-density lipoprotein.

Table 3 Correlation Between Serum Lipid Profile and Different Study Parameters

Lipid Profile (mg/dl)	TC		TG		HDL-C		LDL-C		VLDL-C
	r	P-value	r	P-value	r	P-value	r	P-value	r	P-value
Age (years)	0.072	0.553	0.083	0.497	−0.116	0.344	0.064	0.596	−0.103	0.398
VAS	0.31	0.039*	0.206	0.087	0.004	0.972	0.208	0.083	0.023	0.852
RQLQ score	0.247	0.04*	−0.099	0.416	0.045	0.714	−0.041	0.736	−0.19	0.115
Total IgE (IU/mL)	0.124^#	0.305	0.207^#	0.086	−0.086^#	0.481	0.127^#	0.293	0.063^#	0.603
IL-17A (pg/mL)	0.121^#	0.319	0.303^#	0.011*	−0.251^#	0.036*	0.242^#	0.043*	−0.001^#	0.991

Notes: r: Pearson correlation coefficient; *p<0.05 is statistically significant. ^#Spearman rank correlation coefficient.

Abbreviations: TG, triglycerides; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; VLDL-C, very-low-density lipoprotein.

Table 4 Correlation Between IL-17A and All of Patients Age, VAS, RQLQ, and Total IgE

Variables	IL-17A
	r	P
Age (years)	0.225	0.033*
BMI (kg/m^2)	0.012	0.914
VAS	0.302	0.011*
RQLQ score	−0.008	0.944
Total IgE (IU/mL)	0.109^#	0.368

Notes: r: Pearson correlation coefficient. *p<0.05 is statistically significant. ^#Spearman rank correlation coefficient.