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Original Research

Characteristics of Treated Asthmatics Experiencing Exacerbations in a US Database: A Retrospective Cohort Study

, , ORCID Icon, &
Pages 755-771 | Published online: 01 Jul 2021

Figures & data

Figure 1 NHLBI step diagram – illustrates the step-based categorization based on patients' treatment recommended by NHLBI.

Note: Adapted from National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health; U.S. Department of Health and Human Services. Expert panel report 3: guidelines for the diagnosis and management of asthma. Available from: https://www.nhlbi.nih.gov/health-topics/guidelines-for-diagnosis-management-of-asthma .Citation21
Abbreviations: EIB, exercise-induced bronchoconstriction; ICS, inhaled corticosteroid; LABA, long-acting beta agonists; LTRA, leukotriene receptor antagonist; NHLBI, National Heart, Lung, and Blood Institute; PRN, as required; SABA, short-acting beta agonist.
Figure 1 NHLBI step diagram – illustrates the step-based categorization based on patients' treatment recommended by NHLBI.

Table 1 Description of Patient Demographics, History of Exacerbation(s), NHLBI Step, Comorbid Conditions, and Treatments Ascertained at Index or During the 12-Month Baseline Period

Table 2 Asthma-Related HRU and Cost During the 12-Month Baseline Period for All Patients

Figure 2 Patient flow diagram – describes patient attrition throughout the study and step classification.Abbreviaton: NHLBI, National Heart, Lung, and Blood Institute.

Figure 2 Patient flow diagram – describes patient attrition throughout the study and step classification.Abbreviaton: NHLBI, National Heart, Lung, and Blood Institute.

Figure 3 Exacerbations during the follow-up period (2014) by NHLBI step (n=10,590) – bar chart shows the proportion of patients who experienced an exacerbation in the follow-up period, classified by NHLBI step.

Abbreviations: NHLBI, National Heart, Lung, and Blood Institute.
Figure 3 Exacerbations during the follow-up period (2014) by NHLBI step (n=10,590) – bar chart shows the proportion of patients who experienced an exacerbation in the follow-up period, classified by NHLBI step.

Table 3 Asthma-Related HRU and Cost in All Patients and the Exacerbating Population in the 12-Month Follow-Up Period

Figure 4 Asthma-related HRU during the follow-up period (2014) by NHLBI step for the overall population (N=72,156) – bar charts illustrate the proportion of all patients who required hospitalization (A), ED visit (B), or outpatient department visit (C) during the follow-up period, classified by NHLBI step.

Abbreviations: ED, emergency department; HRU, healthcare resource utilization; NHLBI, National Heart, Lung, and Blood Institute.
Figure 4 Asthma-related HRU during the follow-up period (2014) by NHLBI step for the overall population (N=72,156) – bar charts illustrate the proportion of all patients who required hospitalization (A), ED visit (B), or outpatient department visit (C) during the follow-up period, classified by NHLBI step.

Figure 5 Asthma-related total costs during the follow-up period (2014) by NHLBI step – bar charts illustrate the cost associated with patients in each NHLBI step for both the overall population (A) and for those who experienced ≥1 exacerbation during follow-up (B). Costs were adjusted to 2016 USD ($).

Abbreviations: NHLBI, National Heart, Lung, and Blood Institute; USD, United States dollars.
Figure 5 Asthma-related total costs during the follow-up period (2014) by NHLBI step – bar charts illustrate the cost associated with patients in each NHLBI step for both the overall population (A) and for those who experienced ≥1 exacerbation during follow-up (B). Costs were adjusted to 2016 USD ($).