The Role of Phadiatop Tests and Total Immunoglobulin E Levels in Screening Aeroallergens: A Hospital-Based Cohort Study

Figures & data

Table 1 The Percentage of Subjects with a Positive ImmunoCAP Test in Each Subgroup of Adult and Pediatric Patients

	Adult Group		Pediatric Group
	Subgroup Number	Number (%) of CAP (+)	Subgroup Number	Number (%) of CAP (+)
tIgE (+), Phadiatop (+)	3285	3251 (99.0)	393	390 (99.2)
tIgE (+), Phadiatop (-)	568	102 (18.0)	25	0 (0)
tIgE (-), Phadiatop (+)	1597	1569 (98.2)	56	55 (98.2)
tIgE (-), Phadiatop (-)	3148	178 (5.7)	102	7 (6.9)
Total cases	8598		576

Abbreviations: tIgE, total immunoglobulin E; CAP, ImmunoCAP test.

Table 2 The Sensitivity and Specificity of Each Blood Test to Detect Positive Aeroallergens in Adult and Pediatric Groups

		Adult Group	Pediatric Group
Total IgE level	Sensitivity (%)	65.7	86.3
	Specificity (%)	85.7	77.4
Phadiatop test	Sensitivity (%)	94.5	98.5
	Specificity (%)	98.2	96.8
Combined both tests	Sensitivity (%)	96.5	98.5
	Specificity (%)	84.9	77.9

Abbreviation: IgE, immunoglobulin E.

Table 3 The Positive and Negative Predictive Value of Each Blood Test to Detect Positive Aeroallergens in Adult and Pediatric Groups

		Adult Group	Pediatric Group
Total IgE level	PPV (%)	87.0	93.3
	NPV (%)	63.2	60.8
Phadiatop test	PPV (%)	98.7	99.1
	NPV (%)	92.5	94.5
Combined both tests	PPV (%)	90.3	93.9
	NPV (%)	96.5	93.1

Abbreviations: IgE, immunoglobulin E; PPV, positive predictive value; NPV, negative predictive value.

Figure 1 The ROC curve analysis for optimal cutoff value of serum total IgE level in (A) the adult group, with AUC = 0.85, p < 0.001, cutoff value = 73.8, and (B) the pediatric group, with AUC = 0.87, p < 0.001, cutoff value = 122.0.

Abbreviations: AUC, area under the curve; ROC, receiver operating characteristic; IgE, immunoglobulin E.