Response to Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma and Atopic Phenotypes

Figures & data

Table 1 Patient Baseline Demographics and Clinical Characteristics

	Non-Atopic (N=272)	Atopic (N=181)	Strongly Atopic (N=94)
Age, years, mean (SD)	54 (13)	50 (14)	38 (15)
Gender, female, n (%)	156 (57)	99 (55)	56 (60)
Body mass index, kg/m^2, mean (SD)	27.9 (5.6)	28.3 (6.2)	26.6 (5.9)
Duration of asthma, years, mean (SD)	18 (13)	21 (14)	23 (13)
Proportion of patients on long-term OCS, n (%)	75 (28)	44 (24)	6 (6)
Baseline OCS daily does, mg, mean (SD)	11.4 (8.8)	14.1 (11.7)	9.3 (1.8)
Proportion of patients who received omalizumab	30 (11)	33 (18)	10 (11)
Number of exacerbations in 12 months prior to screening, mean (SD)	3.8 (2.6)	3.5 (2.5)	3.7 (2.9)
Pre-bronchodilator percent predicted FEV1, mean (SD)	60 (18)	62 (19)	63 (17)
Baseline blood eosinophil counts, cells/μL, geometric mean (SD logs)	300 (1.04)	310 (0.97)	280 (0.83)
Baseline total IgE level, U/mL, geometric mean (SD logs)	85 (1.38)	201 (1.30)	608 (1.16)
Sensitivity to different allergens, n (%)
HDMs^a	-	119 (66)	83 (88)
Dog dander	-	72 (40)	69 (73)
Cat dander	-	65 (36)	71 (76)
A. alternata	-	29 (16)	24 (26)
Cockroach	-	44 (24)	36 (38)

Notes: ^aD. pteronyssinus/D. farinae combined.

Abbreviations: FEV₁, forced expiratory volume in 1 second; HDM, house dust mite; IgE, immunoglobulin E; OCS, oral corticosteroid; SD, standard deviation.

Figure 1 Rate ratios for clinically significant exacerbations by atopy/baseline blood eosinophil count status. Atopy was defined according to sensitization to any one of the following allergens: A. alternata, cockroach, HDM, cat dander and dog dander. Non-atopic: class 0 (IgE <0.35 kU/L); atopic: classes 1, 2 and 3 (IgE ≥0.35–17.5 kU/L); strongly atopic: classes 4, 5 and 6 (IgE >17.5 kU/L).

Abbreviations: CI, confidence interval; HDM, house dust mite; IgE, immunoglobulin E; NE, rate ratio could not be estimated due to insufficient patient numbers.

Figure 2 Rate ratios for clinically significant exacerbations by HDM sensitivity. HDM-sensitive (classes 1–6: IgE ≥0.35 kU/L to D. farinae and/or D. pteronyssinus) or HDM non-sensitive (class 0: IgE <0.35 kU/L to D. farinae and/or D. pteronyssinus). Within these categories, patients were grouped according to sensitivity to other allergens (A. alternata, cockroach, cat dander or dog dander; classes 1–6: ≥0.35 kU/L) to ≥1, ≥2 or ≥3 additional allergens.

Abbreviations: CI, confidence interval; HDM, house dust mite; IgE, immunoglobulin E; NE, rate ratio could not be estimated due to insufficient patient numbers.

Figure 3 Change from baseline in ACQ-5 score at Week 32 by atopy and baseline blood eosinophil count categories. Atopy was defined according to sensitization to any one of the following allergens: A. alternata, cockroach, HDM, cat dander and dog dander. Non-atopic: class 0 (IgE <0.35 kU/L; atopic: classes 1, 2 and 3 (IgE 0.35–17.5 kU/L); strongly atopic: classes 4, 5 and 6 (IgE 17.6–>100 kU/L).

Abbreviations: ACQ, asthma control questionnaire; CI, confidence interval; HDM, house dust mite; IgE, immunoglobulin E; LS, least squares; NE, rate ratio could not be estimated due to insufficient patient numbers.

Figure 4 Change from baseline in ACQ-5 score at Week 32 by HDM sensitivity. HDM-sensitive (classes 1–6: IgE ≥0.35 kU/L to D. farinae and/or D. pteronyssinus) or HDM non-sensitive (class 0: IgE <0.35 kU/L to D. farinae and/or D. pteronyssinus). Within these categories, patients were grouped according to HDM sensitivity (classes 1–6: ≥0.35 kU/L) and to additional allergens (ie ≥1, ≥2 or ≥3 additional allergens; A. alternata, cockroach, cat dander or dog dander).

Abbreviations: ACQ, asthma control questionnaire; CI, confidence interval; HDM, house dust mite; IgE, immunoglobulin E; LS, least squares.