Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics

Figures & data

Figure 1 Regulation of bronchial constriction. Nutraceuticals with potential for intervening in this process are highlighted in bold. i–intracellular.

Figure 2 The multiple roles of NADPH oxidase-driven oxidative stress in the pathogenesis of asthma. Nutraceuticals with potential for intervening in this process are highlighted in bold.

Table 1 Proposed Nutraceutical Strategies for Controlling Asthma

Nutraceutical	Mode of Action	Dose Range/Day
PhyCB	Inhibit NADPH Oxidase Complexes	100 mg (or 15 g spirulina)
NAC	Support Glutathione Synthesis and Expression of Antioxidant Enzymes:	600 mg, x2-3
Lipoic Acid		600 mg, x2-3
Glycine		5–10 g, x2-3
Selenium		50–100 mcg
Zinc		10–25 mg, x2
Citrulline	Support NO Biosynthesis/Bioactivity:	2–3 g, x2
High-Dose Folate		10–80 mg
High-Dose Biotin		10 mg, x2-3
NAC	Support H2S Biosynthesis:	600 mg, x2-3
Taurine		1–3 g, x2
Glycine	Dilate Bronchioles:	5–10 g, x2-3
Magnesium		100–200 mg, x2