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Journal of Asthma and Allergy Volume 15, 2022 - Issue
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Original Research

Real World Biologic Use and Switch Patterns in Severe Asthma: Data from the International Severe Asthma Registry and the US CHRONICLE Study

Andrew N Menzies-Gow1 UK Severe Asthma Network and National Registry, Royal Brompton & Harefield Hospitals, London, UKView further author information
,
Claire McBrien2 Kingston Hospital, London, UKView further author information
,
Bindhu Unni3 Observational and Pragmatic Research Institute, Singapore, SingaporeView further author information
,
Celeste M Porsbjerg4 Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, DenmarkView further author information
,
Mona Al-Ahmad5 Al-Rashed Allergy Center, Ministry of Health, Microbiology Department, Faculty of Medicine, Kuwait University, Kuwait, KuwaitORCID Iconhttps://orcid.org/0000-0003-2950-5363View further author information
ORCID Icon,
Christopher S Ambrose6 AstraZeneca, Gaithersburg, MD, USAORCID Iconhttps://orcid.org/0000-0003-4175-7336View further author information
ORCID Icon,
Karin Dahl Assing7 Department of Respiratory Medicine, Aalborg University Hospital, Aalborg, DenmarkView further author information
,
Anna von Bülow4 Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, DenmarkView further author information
,
John Busby8 UK Severe Asthma Network and National Registry, Queen’s University Belfast, Belfast, Northern IrelandView further author information
,
Borja G Cosio9 Son Espases University Hospital-IdISBa-Ciberes, Mallorca, SpainORCID Iconhttps://orcid.org/0000-0002-6388-8209View further author information
ORCID Icon,
J Mark FitzGerald10 The Centre for Lung Health, Vancouver Coastal Health Research Institute, UBC, Vancouver, CanadaView further author information
,
Esther Garcia Gil11 AstraZeneca, Barcelona, SpainView further author information
,
Susanne Hansen12 Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, DenmarkView further author information
,
Liam G aHeaney8 UK Severe Asthma Network and National Registry, Queen’s University Belfast, Belfast, Northern IrelandView further author information
,
Mark Hew13 Allergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, Australia;14 Public Health and Preventive Medicine, Monash University, Melbourne, AustraliaView further author information
,
David J Jackson15 UK Severe Asthma Network andNational Registry, Guy’s and St Thomas’ NHS Trust, London, UK;16 School of Immunology & Microbial Sciences, King’s College London, London, UKView further author information
,
Maria Kallieri17 2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, GreeceView further author information
,
Stelios Loukides17 2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, GreeceORCID Iconhttps://orcid.org/0000-0002-4278-9922View further author information
ORCID Icon,
Njira L Lugogo18 Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USAView further author information
,
Andriana I Papaioannou17 2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, GreeceORCID Iconhttps://orcid.org/0000-0001-9708-3241View further author information
ORCID Icon,
Désirée Larenas-Linnemann19 Directora Centro de Excelencia en Asma y Alergia, Hospital Médica Sur, Ciudad de México, MexicoORCID Iconhttps://orcid.org/0000-0002-5713-5331View further author information
ORCID Icon,
Wendy C Moore20 Pulmonary, Critical Care, Allergy, and Immunologic Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USAView further author information
,
Luis A Perez-de-Llano21 Department of Respiratory Medicine, Hospital Universitario Lucus Augusti, Lugo, SpainORCID Iconhttps://orcid.org/0000-0003-2652-6847View further author information
ORCID Icon,
Linda M Rasmussen22 Allergy Clinic, Department of Dermato-Allergology, Gentofte Hospital, Copenhagen, DenmarkView further author information
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Johannes M Schmid23 University Hospital of Aarhus, Aarhus, DenmarkView further author information
,
Salman Siddiqui24 University of Leicester, Department of Respiratory Sciences & NIHR Leicester Biomedical Research Centre (Respiratory Theme), Leicester, UKView further author information
,
Marianna Alacqua25 AstraZeneca, Cambridge, UKView further author information
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Trung N Tran6 AstraZeneca, Gaithersburg, MD, USAView further author information
,
Charlotte Suppli Ulrik26 Department of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Hvidovre, DenmarkORCID Iconhttps://orcid.org/0000-0001-8689-3695View further author information
ORCID Icon,
John W Upham27 Diamantina Institute & PA-Southside Clinical Unit, The University of Queensland, Brisbane, AustraliaView further author information
,
Eileen Wang28 Division of Allergy & Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, USA;29 Division of Allergy & Clinical Immunology, Department of Internal Medicine, University of Colorado School of Medicine, Aurora, CO, USAView further author information
,
Lakmini Bulathsinhala3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
,
Victoria A Carter3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
,
Isha Chaudhry3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
,
Neva Eleangovan3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
,
Ruth B Murray3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
,
Chris A Price3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
&
David B Price3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UK;31 Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9728-9992View further author information
ORCID Icon show all
Pages 63-78 | Published online: 13 Jan 2022

Figures & data

Figure 1 Subject disposition and pattern of biologic use of patients enrolled into ISAR or CHRONICLE.

Abbreviations: ISAR, International Severe Asthma Registry; Bx, biologic.
Figure 1 Subject disposition and pattern of biologic use of patients enrolled into ISAR or CHRONICLE.

Figure 2 Proportion of patients with severe asthma enrolled into ISAR or CHRONICLE (n= 3531) on each biologic (first use) by year.

Abbreviation: ISAR, International Severe Asthma Registry.
Figure 2 Proportion of patients with severe asthma enrolled into ISAR or CHRONICLE (n= 3531) on each biologic (first use) by year.

Table 1 Pattern of Biologic Use Overall and by Country for Patients with Severe Asthma Enrolled into ISAR and CHRONICLE

Figure 3 Time to biologic cessation for patients with severe asthma enrolled into ISAR or CHRONICLE who stopped or switched biologic (from 2018 onwards).

Abbreviation: ISAR, International Severe Asthma Registry.
Figure 3 Time to biologic cessation for patients with severe asthma enrolled into ISAR or CHRONICLE who stopped or switched biologic (from 2018 onwards).

Figure 4 Pattern of biologic switch for patients with severe asthma enrolled into ISAR or CHRONICLE those who switched once (n=377). Patterns are mutually exclusive; │: or, <, >: sequence of switch; +: add-on use.

Abbreviations: IgE, immunoglobulin E; ISAR, International Severe Asthma Registry; IL, interleukin.
Figure 4 Pattern of biologic switch for patients with severe asthma enrolled into ISAR or CHRONICLE those who switched once (n=377). Patterns are mutually exclusive; │: or, <, >: sequence of switch; +: add-on use.

Table 2 Demographic and Clinical Characteristics of Patients with Severe Asthma Enrolled into ISAR or CHRONICLE, Prior to First Biologic, According to Pattern of First Biologic Use

Table 3 Reasons Why eCRF Patients with Severe Asthma Enrolled into ISAR or CHRONICLE Stopped or Switched Their First Prescribed Biologic

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