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Journal of Asthma and Allergy Volume 15, 2022 - Issue
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Original Research

Cross-Reacting Carbohydrate Determinants Inhibitor Can Improve the Diagnostic Accuracy in Pollen and Food Allergy

Hao ChenDepartment of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-6959-5450View further author information
ORCID Icon,
Qing JiangDepartment of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of ChinaView further author information
,
Yaqi YangDepartment of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of ChinaView further author information
,
Wei ZhangDepartment of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of ChinaView further author information
,
Lin YangDepartment of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of ChinaView further author information
&
Rongfei ZhuDepartment of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2103-3381View further author information
ORCID Icon
Pages 713-725 | Published online: 23 May 2022

Figures & data

Table 1 Clinical Characteristics of the Included Patients

Figure 1 sIgE level of the allergen extracts panel before and after CCD inhibition.

Notes: d1: Dermatophagoides pteronyssinus, d2: Dermatophagoides farinae, d201: blomia tropicalis, e1: cat dander, e5: dog dander, i6: cockroach, k74: silk, w1: ragweed, w6: Artemisia, w22: Humulus, w10-w14: Chenopodium album/redroot amaranth, t6-t3: Juniperus formosana/birch, t11-t15: Platanus acerifolia/ash, txchn1: alder/poplar/willow/beech/oak/walnut, gxchn: lipnica/ryegrass/timothy, txchn2: maple/mulberry/acacia/elm/cypress/broussonetia, m3: aspergillus fumigatus, mx4: candida/penicillium spot/mycospora/Alternaria/aspergillus niger, f75: egg yolk, f1: egg white, f2: milk, f13-f14: peanut/soybean, f10: sesame, f4-f11: wheat/buckwheat, fnutchn2: cashews/pistachios/hazelnuts/almonds/walnuts, f27-f88: beef/lamb, f3: fish, f23-f24: shrimp/crab, ffruchn: peach/apple/mango/lychee/strawberry. ns: not statistically significant.
Figure 1 sIgE level of the allergen extracts panel before and after CCD inhibition.

Table 2 Positive Rate of sIgE Before and After CCD Inhibition

Figure 2 Class of sIgE level before and after CCD inhibition.

Notes: “class 1 to 3” means sIgE ≥0.35 to <17.50 IU/mL, “class 4 to 6” means sIgE ≥17.5IU/mL.
Abbreviation: CCD, cross-reacting carbohydrate determinants.
Figure 2 Class of sIgE level before and after CCD inhibition.

Figure 3 Correlation of sIgE before and after CCD inhibition (A and B). (A) Correlation of sIgE before CCD inhibition; (B) correlation of sIgE after CCD inhibition.

Abbreviation: CCD, cross-reacting carbohydrate determinants.
Figure 3 Correlation of sIgE before and after CCD inhibition (A and B). (A) Correlation of sIgE before CCD inhibition; (B) correlation of sIgE after CCD inhibition.

Figure 4 Consistency of SPT, sIgE against pollen and food and allergic symptoms before and after CCD inhibition (A–D). (A) Consistency of SPT and sIgE against pollen and food before and after CCD inhibition. (B) Consistency of symptoms in spring and SPT, symptoms and sIgE against pollen and food before and after CCD inhibition. (C) Consistency of symptoms in autumn and SPT, symptoms and sIgE against pollen and food before and after CCD inhibition. (D) Consistency of symptoms after ingest food and SPT, symptoms and sIgE against pollen and food before and after CCD inhibition.

Abbreviations: CCD, cross-reacting carbohydrate determinants; SPT, skin prick test; sIgE (before), sIgE before CCD inhibition; sIgE (after), sIgE after CCD inhibition.
Figure 4 Consistency of SPT, sIgE against pollen and food and allergic symptoms before and after CCD inhibition (A–D). (A) Consistency of SPT and sIgE against pollen and food before and after CCD inhibition. (B) Consistency of symptoms in spring and SPT, symptoms and sIgE against pollen and food before and after CCD inhibition. (C) Consistency of symptoms in autumn and SPT, symptoms and sIgE against pollen and food before and after CCD inhibition. (D) Consistency of symptoms after ingest food and SPT, symptoms and sIgE against pollen and food before and after CCD inhibition.

Figure 5 Symptoms and sensitization of pollen and food before and after CCD inhibition.

Abbreviation: CCD, cross-reacting carbohydrate determinants.
Figure 5 Symptoms and sensitization of pollen and food before and after CCD inhibition.

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