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ORIGINAL RESEARCH

Analysis of Cytokine Production Profiles of Local and Systemic Lymphocytes in Sick Building Syndrome Compared with Ocular Allergy

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 1115-1124 | Received 17 May 2022, Accepted 29 Jul 2022, Published online: 22 Aug 2022

Figures & data

Table 1 Criteria for Clinical Evaluation of Allergic Ocular Findings

Figure 1 Percentage of IFN-γ-producing CD4+ T cells in PBMC. The results are expressed in percent as mean ± SEM (*P < 0.05).

Abbreviations: PBMC, peripheral blood mononuclear cells; SBS, sick building syndrome; AC, allergic conjunctivitis; AKC, atopic keratoconjunctivitis; VKC, vernal keratoconjunctivitis.
Figure 1 Percentage of IFN-γ-producing CD4+ T cells in PBMC. The results are expressed in percent as mean ± SEM (*P < 0.05).

Figure 2 Percentage of IL-4-producing CD4+ T cells in PBMC. The results are expressed in percent as mean ± SEM (***P < 0.001).

Figure 2 Percentage of IL-4-producing CD4+ T cells in PBMC. The results are expressed in percent as mean ± SEM (***P < 0.001).

Figure 3 Percentage of IFN-γ-producing CD4+ T cells in conjunctiva. The results are expressed in percent as mean ± SEM (*P < 0.05; **P < 0.01; ***P < 0.001).

Figure 3 Percentage of IFN-γ-producing CD4+ T cells in conjunctiva. The results are expressed in percent as mean ± SEM (*P < 0.05; **P < 0.01; ***P < 0.001).

Figure 4 Percentage of IL-4-producing CD4+ T cells in conjunctiva. The results are expressed in percent as mean ± SEM (**P < 0.01; ***P < 0.001; ****P<0.0001).

Figure 4 Percentage of IL-4-producing CD4+ T cells in conjunctiva. The results are expressed in percent as mean ± SEM (**P < 0.01; ***P < 0.001; ****P<0.0001).

Table 2 Correlation Between Percentage of IFN-γ- or IL-4-Producing CD4+ T Cells in PBMC or Conjunctiva and Clinical Score in Patients with SBS

Figure 5 Correlation between percentage of IL-4-producing CD4+ T cells in conjunctiva and clinical score in patients with SBS. Correlation coefficient between percentage of IL-4-producing CD4+ T cells in conjunctiva and clinical score was significant (P = 0.0025, Spearman’s rank test).

Figure 5 Correlation between percentage of IL-4-producing CD4+ T cells in conjunctiva and clinical score in patients with SBS. Correlation coefficient between percentage of IL-4-producing CD4+ T cells in conjunctiva and clinical score was significant (P = 0.0025, Spearman’s rank test).