Anaphylaxis Following Contrast-Enhanced CT with Iodixanol: A Case Report and Literature Review

Figures & data

Table 1 Summary of Case Reports of Anaphylactic Reactions and Organ Damage Related Iodixanol

Report	Age, y	Sex	Patient Characteristics	Iodixanol Injection/Onset of Adverse Reaction	Presentation	Outcome
Tokiyoshi et al (2002)^Citation21	79	F	Right recurrent nerve plasy	50 seconds after contrast medium bolus injection	Apneic, fatal anaphylactoid shock, marked laryngeal edema and extensive mast cell infiltration	Cardiopulmonary resuscitation, but died
Won-Wook et al (2004)^Citation22	45	M	Substernal pain, cardiac catheterisation	5 minutes after iodixanol to the left coronary	Itching, dizziness, urticarial, cyanosis, hypotension	Fluid resuscitation and vasopressors, recovered 1 hour later
Alcoceba et al (2009)^Citation23	61	M	Thoracic pain, cardiac catheterisation	300 mL of iodixanol, 5 minutes after receiving iodixanol	Itching, heat, dyspnea and cardiac respiratory arrest	Hospitalized in ICU, improved at 48 hours
Emiliano et al (2011)^Citation24	76	F	Coronary artery disease, recurrent transient ischemic attacks		Aphasia, stupor, and full hemiparesis	Anti-edema drugs, recovery within 48 hours
Jun et al (2017)^Citation25	58	F	Multiple intracranial aneurysms, hypertension, hypothyroidism, peripheral, arteryocclusive disease	220 mL of iodixanol, a few hours after procedure	Fever, sulcal obliteration of right cerebral hemisphere, left hemiparesis involving face, arm and leg (grade 3/5), sensory loss, and left-sided neglect with drowsy mentality	Hydration with enough fluid, and intravenous dexamethasone, mannitol and anticonvulsant, recovered on day 6

Abbreviations: F, female; M, male; NR, not report; ICU, intensive care unit.

Shimizu T, Kawasaki Y, Ochiai E, et al. [A fatal case of anaphylactoid shock after administration of nonionic contrast medium]. Nihon Igaku Hoshasen Gakkai Zasshi. 2002;62(13):749–750. Japanese.

 PubMedGoogle Scholar

Choi WW. A case of anaphylactoid reaction to nonionic contrast agent, Iodixanol (Visipaque(R)) during coronary angiography. Korean J Med. 2004;91:4.

 Google Scholar

Alcoceba E, Gaig P. Anaphylaxis reaction to iodixanol during coronary angiography. Allergy. 2009;64(7):1103–1104. doi:10.1111/j.1398-9995.2009.01997.x

 PubMed Web of Science ®Google Scholar

Chisci E, Setacci F, de Donato G, et al. A case of contrast-induced encephalopathy using iodixanol. J Endovasc Ther. 2011;18(4):540–544. doi:10.1583/11-3476.1

 PubMed Web of Science ®Google Scholar

Park JC, Ahn JH, Chang IB, et al. A case of unusual presentation of contrast-induced encephalopathy after cerebral angiography using iodixanol. J Cerebrovasc Endovasc Neurosurg. 2017;19(3):184–188. doi:10.7461/jcen.2017.19.3.184

 PubMedGoogle Scholar