Safety and Effectiveness of Magnesium Sulphate for Severe Acute Asthma Management Among Under-five Children: Systematic Review and Meta-analysis

Figures & data

Figure 1 PRISMA flow diagram showing the selection of trials included in the review.

Table 1 Characteristics of the Included Trials for the Safety and Efficacy Analysis of MgSO₄

Study	Location	Sample Size	Age (Years)	Asthma Severity	Total MgSO4 Dose	Outcome
Schuh et al 2020^Citation1	Canada	816	Median 4	Severe acute	Nebulized: 600 mg	Hospitalization
Powell et al 2013^Citation12	United Kingdom	505	Mean 4	Severe acute	Nebulized: 250 mmol/L	Hospitalization
Santana. et al 2001^Citation13	Brazil	50	Mean 4.5	Severe acute	IV: 50 mg/kg IV	Respiratory acidosis

Figure 2 The effectiveness of IV MgSO₄ for managing acute severe asthma among children under five.

Figure 3 The safety of IV MgSO₄ for managing acute severe asthma among children under five.

Figure 4 The effectiveness of nebulized MgSO₄ for managing acute severe asthma among children under five.

Figure 5 The safety of nebulized MgSO₄ for managing acute severe asthma among children under five.

Schuh S, Sweeney J, Rumantir M, et al. Effect of nebulized magnesium vs placebo added to albuterol on hospitalization among children with refractory acute asthma treated in the emergency department. JAMA. 2020;324(20):2038–2047. doi:10.1001/jama.2020.19839

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Powell CVE, Boland A, Khan K, et al. Magnesium Trial in Children (MAGNETIC) a randomized, placebo-controlled trial and economic evaluation of nebulized magnesium sulphate in acute severe asthma in children. Health Technol Assess. 2013;17(45):1–216.

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Santana JC, Sérgio Saldanha Menna B, Piva JP, et al. Controlled study on intravenous magnesium sulfate or salbutamol in early treatment of severe acute asthma attack in children. Pediatr. 2001;77(4):279–287. doi:10.2223/JPED.235

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