Role of Chemokines and Inflammatory Cells in Respiratory Allergy

Figures & data

Table 1 Detailed Table of Chemokines and Receptors

Receptor	Chemokine Ligands	Cell Expression	General Immune Function
CCR1	CCL3, CCL3L1, CCL5, CCL8, CCL14, CCL15, CCL16	Monocytes, neu, Th1, macrophages, basophils	Innate immunity and adaptive immunity
CCR2	CCL2, CCL7, CCL8, CCL12, CCL13, CCL16	Monocytes, basophils, macrophages, immature DCs, Th1 cells	Monocyte trafficking and type 1 adaptive immunity
CCR3	CCL5, CCL7, CCL11, CCL13, CCL15, CCL24, CCL26	Eosinophils, basophils and mast cells	Type 2 aptive immunity
CCR4	CCL17, CCL22	T cells, Th2 cells, CD8+ T cells, monocytes, DCs, B cells	Type 2 immune responses
CCR5	CCL3, CCL3L1, CCL4, CCL4L1, CCL5, CCL16	Monocytes, macrophages, Th1 cells, NK cells	Type 1 adaptive immunity
CCR6	CCL20	Th17 cells, DCs, T cells, NKT cells, NK cells	Type 17 adaptive immune, responses
CCR7	CCL19, CCL21	T cells, DCs, and B cells	DCs, B cell and T cell trafficking
CCR8	CCL1, CCL8, CCL18, Trm cells, gd T cells	Th2, Treg cells	Type 2 adaptive immunity
CXCR1	CXCL6, CXCL8	Neutrophils; monocytes, NK cells, mast cells, basophils,	Neutrophil trafficking
CXCR2	CXCL1–CXCL3 CXCL5–CXCL7	Neutrophils; monocytes, NK cells, mast cells, basophils	B cell lymphopoiesis, neutrophil traffificking
CXCR3	CXCL9, CXCL10, CXCL11	Th1 cells, CD8+ Tcm and Tem cells, NK cells, NKT cells	Type 1 adaptive immunity
CXCR4	CXCL12	Leukocytes, endothelial cells	Hematopoiesis, organogenesis and bone marrow homing
CXCR5	CXCL13	B cells, Tfh cells, Tfr cells	B and T cell trafficking
CXCR6	CXCL16	Th1 cells, Th17 cells, ILCs, NKT cells, NK cells	ILC function and adaptive immunity

Figure 1 Inflammatory cells and some chemokines, the role of cytokines in respiratory epithelial allergy.

Figure 2 Plot of the relationships between TH cells and their secreted cytokines and associated inflammatory cells.

Figure 3 Mechanism of action of eosinophils, neutrophils and ILC2 in allergy.