Blueberry (Vaccinium myrtillus) Induced Anaphylaxis in a Chinese Child with Lipid Transfer Protein Sensitization

Figures & data

Table 1 In vitro Allergy Diagnostics: Specific IgE-Antibody Detection Results (Immuno CAP)

Allergen and Allergen Component	IgE, kUa/L	CAP Class
T-IgE	192
Aeroallergens
d1 (Dermatophagoides pteronyssinus)	2.89	2
d2 (Dermatophagoides farina)	13.2	3
t6 (mountain juniper)	2.23	2
w22 (Japanese hop)	74.3	5
w6 (mugwort)	26.5	4
m3 (Asperigillus fumigatus)	Neg	0
m6 (Alternaria alternata)	Neg	0
e1 (cat dander)	Neg	0
e5 (dog dander)	Neg	0
t3 (common sliver birch)	Neg	0
t11 (maple leaf sycamore, London plane)	Neg	0
g2 (Bermuda grass)	Neg	0
g6 (Timothy grass)	Neg	0
w1 (Common ragweed)	Neg	0
Foods
f14 (soybean)	Neg	0
f1 (egg white)	Neg	0
f2 (milk)	Neg	0
f4 (wheat)	Neg	0
f13 (peanut)	Neg	0
f23 (crab)	Neg	0
f24 (shrimp)	Neg	0
Allergen components
f420 (rPru p3, LTP, peach)	2.15	2
f416 (rTri a19, omega-5 gliadin, wheat)	Neg	0
f433 (rTri a14, LTP wheat)	2.24	2
w231 (nArt v1 mugwort)	0.97	2
w233 (nArt v3 mugwort)	48.4	4
Prick-to-prick testing
Allergens	PPT results given in mm wheal diameter	PPT class
Wheat protein (water/dilute saline soluble)	3.5	++
gliadin (75% alcohol soluble)	0	Negative
Blueberry	9.5	++++
Cherry	6.5	++++
Kiwifruit	6	++++
Pear	4.5	++
Litchi	4	++
Cherry tomato	2.5	+
Pineapple	2.5	+
Controls
Histamine	5
0.9% NaCl	0

Notes: +wheal diameter 1/3 to 2/3 the size of the wheal produced by histamine. ++wheal diameter more than 2/3 but less than a full wheal diameter produced by histamine. ++++wheal diameter larger than the wheal produced by histamine and accompanied by pseudopods.

Figure 1 Legends: Prick-to-prick testing for 22 fruits and wheat allergens (water/dilute soluble allergens and gliadins soluble in 75% alcohol) shows strong positive results for blueberry (wheal size 9.5mm), cherry (wheal size 6.5mm), kiwifruit (wheal size 6mm), and pear (wheal size 4.5mm). A positive score was considered negative if it was less than 1/3 of the wheal diameter or if it was not different from saline.