High Serum Allergen-Specific IgE of House Dust Mite in Predicting the Risk of Comorbidity in Children with Allergic Conjunctivitis

Figures & data

Table 1 Demographic and Clinical Characteristics of the Study Population

	n	%
Sex
Boys	2015	67.80
Girls	957	32.20
Age(months)
3~12	1695	57.03
12~36	651	21.90
48~72	469	15.78
72~144	157	5.28
Comorbidity
Allergic Asthma (AA)	866	29.14
Allergic rhinitis (AR)	1857	62.48
Atopic dermatitis (AD)	610	20.52
Allergens sIgE
Negative (n,%)	930	31.29
Positive (n,%)	2042	68.71
Monosensitisation (n,%)	878	29.54
Polysensitisation (n,%)	1164	39.17

Table 2 Positive Distribution of sIgE of Different Allergens

Inhaled Allergens (n=2972)			Ingested Allergens (n=2972)
Species	n	%	Species	N	%
HDM	1290	43.41	Milk	579	19.48
Cat dander	181	6.09	Egg white	553	18.61
Pollen tree (Poplar, Willow, Elm)	122	4.10	Beef	460	15.48
			Soybean	224	7.54
Ragweed	122	4.10	Freshwater fish	188	6.33
Mugwort	116	3.90	Crab	188	6.33
Cockroach	82	2.76	Marine fish	186	6.26
Mould	59	1.99	Peanut	125	4.21
Dog dander	58	1.95	Mutton	116	3.90
Humulus lupulus	56	1.88	Shrimp	100	3.36

Table 3 Positive Distribution of sIgE at Different Age Groups

Allergens	3~12m (n=1695)	12~36m (n=651)	48~72m (n=469)	>72m (n=157)	χ2trend	Ptrend
HDM	650(38.35)	306(47)	249(53.09)	85(54.14)	−6.6362	<0.0001***
Cat dander	90(5.31)	38(5.84)	43(9.17)	10(6.37)	−2.3812	0.0173
Elm/Willow/Poplar	53(3.13)	28(4.3)	26(5.54)	15(9.55)	−4.0664	<0.0001***
Ragweed	60(3.54)	26(3.99)	23(4.9)	13(8.28)	−2.6585	0.0078**
Mugwort	52(3.07)	26(3.99)	26(5.54)	12(7.64)	−3.4611	0.0005***
Cockroach	44(2.6)	18(2.76)	10(2.13)	10(6.37)	−1.3597	0.1739
Dog dander	37(2.18)	9(1.38)	9(1.92)	3(1.91)	0.6061	0.5445
Mould	29(1.71)	13(2)	10(2.13)	7(4.46)	−1.8744	0.0609
Humulus lupulus	23(1.36)	12(1.84)	16(3.41)	5(3.18)	−2.9618	0.0031**
Milk	451(26.61)	88(13.52)	32(6.82)	8(5.1)	11.3508	<0.0001***
Egg white	381(22.48)	105(16.13)	60(12.79)	7(4.46)	7.0393	<0.0001***
Beef	275(16.22)	96(14.75)	40(8.53)	49(31.21)	−0.2293	0.8186
Soybean	128(7.55)	44(6.76)	37(7.89)	15(9.55)	−0.5848	0.5587
Marine fish	98(5.78)	34(5.22)	42(8.96)	12(7.64)	−2.0656	0.0389*
Crab	92(5.43)	41(6.3)	41(8.74)	14(8.92)	−2.8433	0.0045**
Peanut	75(4.42)	17(2.61)	22(4.69)	11(7.01)	−0.7314	0.4646
Mutton	91(5.37)	15(2.3)	9(1.92)	1(0.64)	4.5744	<0.0001***
Freshwater fish	123(7.26)	32(4.92)	24(5.12)	9(5.73)	1.9105	0.0561
Shrimp	50(2.95)	19(2.92)	24(5.12)	7(4.46)	−2.0676	0.0387*

Notes: *P<0.05 **P<0.01 ***P<0.001.

Table 4 Positive Rates of sIgE in Children with Different Comorbidities

	AC (n=660)	AC+1 comobidity (n=1428)	AC+2 comobidities (n=747)	AC+3 comobidities (n=137)	χ2trend	Ptrend
Allergen (-) n (%)	40 (61.67)	364 (25.49)	144 (19.28)	15 (10.95)	−17.0672	<0.0001***
Allergens (+) n (%)	253(38.33)	1064(74.51)	603(80.72)	122(89.05)
Monosensitisation n (%)	140(55.34)	463(43.52)	244(40.46)	31(25.41)	−5.2767	<0.0001***
Polysensitisation n (%)	113(44.66)	601(56.48)	359(59.54)	91(74.59)

Note: ***P<0.001.

Table 5 The Risk of Allergic Morbidities at Different Level of HDM Sensitivity

The number of comorbidity	HDM sensitivity	OR	95% CI	P value
One comorbidity	Level 1	102.993	14.343–739.546	<0.0001
	Level 2	92.152	12.821–662.365	<0.0001
	Level 3	105.703	14.724–758.841	<0.0001
	Level 4	136.419	19.039–977.502	<0.0001
	Level 5	197.828	27.668->999.999	<0.0001
Two comorbidities	Level 1	123.24	16.967–895.18	<0.0001
	Level 2	146.063	20.165->999.999	<0.0001
	Level 3	175.732	24.323->999.999	<0.0001
	Level 4	273.864	38.078->999.999	<0.0001
	Level 5	330.878	46.076->999.999	<0.0001
Three comorbidities	Level 1	305.667	38.9->999.999	<0.0001
	Level 2	305.667	38.9->999.999	<0.0001
	Level 3	371.166	47.796->999.999	<0.0001
	Level 4	720.492	95.31->999.999	<0.0001
	Level 5	633.08	83.425->999.999	<0.0001