Hematological parameters in Ghanaian sickle cell disease patients

Figures & data

Table 1 Hematological parameters of male and female HbSS patients in steady state

Parameters	Male (n=110) (mean±SD)	Female (n=98) (mean±SD)	P-value
Hb (g/dL)	8.53±1.61	8.31±1.57	0.3128
HCT (%)	25.82±5.15	24.84±5.18	0.1705
RBC (10^6/mm^3)	3.06±0.71	2.89±0.77	0.0892
MCV (µm^3)	84.97±8.47	87.44±8.83	0.0411*
MCH (pg)	28.20±3.51	29.42±3.60	0.0145*
MCHC (g/dL)	33.12±1.46	33.59±1.44	0.0205*
RDW (%)	18.56±2.54	17.82±2.68	0.0431*
MPV (µm^3)	7.47±0.69	7.32±0.70	0.1197
PDW (%)	13.92±2.26	14.10±1.96	0.5275
PLT (10^3/mm^3)	466.33±121.39	461.95±160.55	0.8236
PCT (%)	0.35±0.10	0.33±0.11	0.3045
WBC (10^3/mm^3)	12.18±3.56	10.69±3.11	0.0016*

Note:

* Significant.

Abbreviations: HCT, hematocrit; Hb, hemoglobin; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean cell volume; MPV, mean platelet volume; PCT, plateletcrit; PDW, platelet distribution width; PLT, platelets; RBC, red blood cell; RDW, red cell distribution width; WBC, white blood cells.

Table 2 Hematological parameters of male and female HbSS patients in VOC

Parameters	Male (n=64) (mean±SD)	Female (n=92) (mean±SD)	P-value
Hb (g/dL)	9.24±1.67	8.42±1.68	0.0035*
HCT (%)	28.37±6.01	25.58±5.74	0.0034*
RBC (10^6/mm^3)	3.50±0.89	3.05±0.87	0.0015*
MCV (µm^3)	82.59±9.45	85.50±9.45	<0.001*
MCH (pg)	27.50±6.95	28.40±4.02	0.3078
MCHC (g/dL)	33.03±4.92	33.11±1.69	0.8848
RDW (%)	18.56±2.89	17.39±2.20	0.0048*
MPV (µm^3)	7.65±0.81	7.62±0.70	0.8213
PDW (%)	13.19±3.01	13.53±2.74	0.4707
PLT (10^3/mm^3)	439.34±158.77	459.09±193.64	0.5019
PCT (%)	0.34±0.12	0.35±0.14	0.6394
WBC (10^3/mm^3)	16.24±7.37	13.01±4.83	0.0012*

Note:

* Significant.

Abbreviations: HCT, hematocrit; Hb, hemoglobin; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean cell volume; MPV, mean platelet volume; PCT, plateletcrit; PDW, platelet distribution width; PLT, platelets; RBC, red blood cell; RDW, red cell distribution width; WBC, white blood cells; VOC, vaso-occlusive crises.

Table 3 Hematological parameters of male and female HbSC patients in steady state

Parameters	Male (n=30) (mean±SD)	Female (n=52) (mean±SD)	P-value
Hb (g/dL)	12.51±1.33	10.74±1.73	<0.001*
HCT (%)	39.83±4.63	33.02±7.08	<0.001*
RBC (10^6/mm^3)	4.82±0.49	4.04±0.94	0.0001*
MCV (µm^3)	82.90±5.15	81.96±8.53	0.5860
MCH (pg)	26.02±1.83	26.61±2.26	0.4225
MCHC (g/dL)	30.02±1.83	31.86±1.15	0.308
RDW (%)	14.97±1.35	15.01±2.58	0.9367
MPV (µm^3)	8.32±1.01	8.23±1.01	0.9657
PDW (%)	14.23±2.23	12.66±2.89	0.0117*
PLT (10^3/mm^3)	289.64±18.31	322.87±20.70	0.2492
PCT (%)	0.23±0.08	0.26±0.09	0.1980
WBC (10^3/mm^3)	6.87±1.77	9.32±2.56	0.0219*

Note:

* Significant.

Abbreviations: HCT, hematocrit; Hb, hemoglobin; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean cell volume; MPV, mean platelet volume; PCT, plateletcrit; PDW, platelet distribution width; PLT, platelets; RBC, red blood cell; RDW, red cell distribution width; WBC, white blood cells.

Table 4 A comparison of hematological parameters between healthy controls, HbSS, and HbSC male patients with sickle cell disease in steady state and in VOC

Parameters	Control (n=93) (mean±SD)	HbSS steady state (n=110) (mean±SD)	HbSC steady state (n=30) (mean±SD)	HbSS VOC (n=64) (mean±SD)	HbSC VOC (n=12) (mean±SD)	P-value
Hb (g/dL)	15.38±3.68	8.53±1.61	12.51±1.33	9.24±1.67	12.10±1.63	<0.001*
HCT (%)	42.20±6.51	25.82±5.15	39.83±4.63	28.37±6.01	38.35±4.37	<0.001*
RBC (10^6/mm^3)	5.14±0.82	3.06±0.71	4.82±0.49	3.50±0.89	4.45±0.53	<0.001*
MCV (µm^3)	82.62±6.09	84.97±8.47	82.90±5.15	82.59±9.45	84.42±6.20	0.185
MCH (pg)	27.44±2.67	28.20±3.51	26.02±1.83	27.50±6.95	27.20±2.04	0.274
MCHC (g/dL)	33.18±1.36	33.12±1.46	30.02±1.83	33.03±4.92	32.24±0.58	<0.001*
RDW (%)	18.91±13.25	18.56±2.54	14.97±1.35	18.56±2.89	15.43±1.16	<0.001*
MPV (µm^3)	9.09±1.38	7.47±0.69	8.32±1.01	7.65±0.81	7.88±0.77	<0.001*
PDW (%)	13.76±1.92	13.92±2.26	14.23±2.23	13.19±3.01	13.42±2.22	0.0900
PLT (10^3/mm^3)	224.22±61.17	466.33±121.39	289.64±18.31	439.34±158.77	238.56±109.94	<0.001*
PCT (%)	0.18±0.07	0.35±0.10	0.23±0.08	0.34±0.12	0.19±0.07	<0.001*
WBC (10^3/mm^3)	5.31±1.11	12.18±3.56	6.87±1.77	16.24±7.37	9.78±2.09	<0.001*

Note:

* Significant.

Abbreviations: HCT, hematocrit; Hb, hemoglobin; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean cell volume; MPV, mean platelet volume; PCT, plateletcrit; PDW, platelet distribution width; PLT, platelets; RBC, red blood cell; RDW, red cell distribution width; VOC, vaso-occlusive crises; WBC, white blood cells.

Table 5 A comparison of hematological parameters between healthy controls, HbSS, and HbSC female patients with sickle cell disease in steady state and in VOC

Parameters	Control (n=93) (mean±SD)	HbSS steady state (n=110) (mean±SD)	HbSC steady state (n=30) (mean±SD)	HbSS VOC (n=64) (mean±SD)	HbSC VOC (n=12) (mean±SD)	P-value
Hb (g/dL)	13.19±3.32	8.31±1.57	10.74±1.73	8.42±1.68	11.26±1.50	<0.001*
HCT (%)	40.91±10.94	24.84±5.18	33.02±7.08	25.58±5.74	35.21±4.66	<0.001*
RBC (10^6/mm^3)	4.97±1.26	2.89±0.77	4.04±0.94	3.05±0.87	4.28±0.56	<0.001*
MCV (µm^3)	82.62±5.29	87.44±8.83	81.96±8.53	85.50±9.45	82.50±7.61	<0.001*
MCH (pg)	26.68±2.05	29.42±3.60	26.61±2.26	28.40±4.02	26.43±2.87	0.5410
MCHC (g/dL)	32.29±0.90	33.59±1.44	31.86±1.15	33.11±1.69	31.96±1.03	0.4588
RDW (%)	18.59±13.25	17.82±2.68	15.01±2.58	17.39±2.20	14.86±1.16	<0.001*
MPV (µm^3)	8.15±1.08	7.32±0.70	8.23±1.01	7.62±0.70	7.94±0.78	<0.001*
PDW (%)	14.91±1.970	14.10±1.95	12.66±2.89	13.53±2.74	12.79±2.22	<0.001*
PLT (10^3/mm^3)	250.82±80.77	461.95±160.55	322.87±20.70	459.09±193.64	319.00±114.88	<0.001*
PCT (%)	0.19±0.06	0.33±0.11	0.26±0.09	0.35±0.14	0.25±0.08	<0.001*
WBC (10^3/mm^3)	5.793±1.28	10.69±3.11	9.32±2.56	13.01±4.83	8.25±1.52	<0.001*

Note:

* Significant.

Abbreviations: HCT, hematocrit; Hb, hemoglobin; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean cell volume; MPV, mean platelet volume; PCT, plateletcrit; PDW, platelet distribution width; PLT, platelets; RBC, red blood cell; RDW, red cell distribution width; VOC, vaso-occlusive crises; WBC, white blood cells.