Post-Transplant Maintenance Therapy for Patients with Acute Myeloid Leukemia: Current Approaches and the Need for More Trials

Figures & data

Table 1 Some of the Ongoing Trials Evaluating Various Targets for Post-Allogeneic Stem Cell Transplantation Strategies

Target	Drug(s)	Clinical Phase	Endpoints	Status	Identifier
FLT3
	Crenolanib	II	PFS; DFS; OS; GVHD; 100-day TRM	Recruiting	NCT02400255
	Gilteritinib	III	RFS, OS, GVHD, EFS	Active, not recruiting	NCT02997202
TP53
	APR-246 + Azacytidine	II	Safety, tolerability, 1-year RFS	Recruiting	NCT03931291
Hh
	Glasdegib	III	DFS	Not yet recruiting	NCT04168502
DNMT
	Low-dose azacytidine	II	OS; relapse rate; safety	Recruiting	NCT01995578
	Azacytidine+ valproic acid	II	OS; time to relapse	Recruiting	NCT02124174
	Oral azacytidine (AMADEUS)	III	RFS, OS, NRM, GVHD	Recruiting	NCT04173533
	SGI-110+ DLI	II	DFS, OS	Not yet recruiting	NCT03454984
BCL-2
	Venetoclax+ azacytidine	I	MTD; OS, RFS; GVHD	Recruiting	NCT03613532
	Venetoclax+ azacytidine	II	RFS, OS, GVHD	Recruiting	NCT04128501
	Venetoclax+ azacytidine (VIALE-T)	III	RFS, OS, GVHD, MRD	Recruiting	NCT04161885
HDAC
	Panobinostat	III	OS, DFS, EFS, NRM, GVHD	Recruiting	NCT04326764
IDH2
	Enasidenib	I	Safety, tolerability, GVHD, RFS	Recruiting	NCT03728335
	Enasidenib	I	MTD, DLT, GVHD	Recruiting	NCT03515512
	Enasidenib	II	OS, RFS, Safety and tolerability	Recruiting	NCT04522895
IL-15
	N-803	II	Relapse rate, GVHD, MRD, OS	Recruiting	NCT02989844

Abbreviations: PFS, progression-free survival; OS, overall survival; RFS, relapse-free survival; EFS, event-free survival; GVHD, graft-versus-host disease; MTD, maximum tolerated dose; DLT, dose-limiting toxicity; DLI, donor lymphocyte infusion; MRD, minimal residual disease; NRM, non-relapse mortality; Hh, hedgehog pathway; DNMT, DNA methyltransferase; HDAC, histone deacetylase.