Plasma Folate Levels in Acutely Ill and Steady State Pediatric Sickle Cell Disease Patients in Ghana

George O Adjei1 Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, Accra, GhanaCorrespondence[email protected]

Abdul M Sulley1 Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, Accra, Ghana

https://orcid.org/0000-0001-7285-365X

Bamenla Q Goka2 Department of Child Health, University of Ghana Medical School, Accra, Ghana

https://orcid.org/0000-0003-2324-3980

Christabel Enweronu-Laryea2 Department of Child Health, University of Ghana Medical School, Accra, Ghana

Seth K Amponsah3 Department of Medical Pharmacology, University of Ghana Medical School, Accra, Ghana

https://orcid.org/0000-0001-7411-0972

Michael Alifrangis4 Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark

Jorgen A L Kurtzhals4 Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark;5 Centre for Medical Parasitology at Department of Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

https://orcid.org/0000-0003-2760-8713

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Figures & data

Table 1 Presenting Symptoms in the Acutely Ill Groups

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Table 2 Baseline Demographic and Clinical Characteristics in Clinical Sub-Groups

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Figure 1 A box plot showing the distribution of baseline folate levels (log base 10) in the various groups: Non SCD, patients without sickle cell disease and confirmed malaria; SCD with positive blood C/S, SCD patients with a positive blood culture; SCD positive for malaria, SCD patients with confirmed malaria; SCD control, SCD patients in steady state. The box represents the interquartile range with median folate levels. The bars represent the maximum and minimum levels.

Figure 2 A box plot showing the distribution of folate (log base 10) at presentation (Day 0), and at follow-up on Day 14, among SCD patients with confirmed malaria. SCD positive for malaria, SCD children with confirmed malaria on Day 0; SCD positive for malaria on Day 14, SCD children with confirmed malaria on Day 14. The box represents the interquartile range with median folate levels. The bars represent the maximum and minimum levels.

Table 3 Selected Characteristics of Participants with Normal or Elevated Folate

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Plasma Folate Levels in Acutely Ill and Steady State Pediatric Sickle Cell Disease Patients in Ghana

Table 1 Presenting Symptoms in the Acutely Ill Groups

Table 2 Baseline Demographic and Clinical Characteristics in Clinical Sub-Groups

Table 3 Selected Characteristics of Participants with Normal or Elevated Folate

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Plasma Folate Levels in Acutely Ill and Steady State Pediatric Sickle Cell Disease Patients in Ghana

Figures & data

Table 1 Presenting Symptoms in the Acutely Ill Groups

Table 2 Baseline Demographic and Clinical Characteristics in Clinical Sub-Groups

Table 3 Selected Characteristics of Participants with Normal or Elevated Folate

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