Correlation of Serum Ferritin and Liver Iron Concentration with Transient Liver Elastography in Adult Thalassemia Intermedia Patients with Blood Transfusion

Figures & data

Table 1 Characteristic Data Based on Demographic Research Subjects

Characteristics	N=45
Gender, n(%)
Female	28(62.2)
Male	17(37.8)
Age, median (IQR)	33(22)
Age group, n(%)
18–30 years	19(42.2)
31–40 years	11(24.4)
41–50 years	10(22.2)
51–60 years	3(6.7)
>60 years	2(4.4)
Thalassemia type, n(%)
Thalassemia α	2(4.4)
Thalassemia β	14(31.1)
Thalassemia βHbE	29(64.4)
Age of thalassemia diagnosis, median (IQR)	20(33)
2–6 years, n(%)	11(24,4)
7–18 years, n(%)	10(22.2)
> 18 years, n(%)	24(53.3)
First transfusion age (years), median (IQR)	19(27)
2–6 years, n(%)	12(26.7)
7–18 years, n(%)	10(22.2)
> 18 years, n(%)	23(52.1)

Table 2 Characteristic Thalassemia-Related Data of Study Subjects

Characteristics	N=45
Transfusion requirement of the year, n (%)
1–3 times a year	7 (15.6)
4–6 times a year	6 (13.3)
> 6 times a year	32 (71.1)
A history of splenectomy, n (%)
Yes	44 (97.8)
No	1 (2.2)
Iron chelation, n (%)
Not getting iron chelating agent	2 (4.4)
Deferiprone	31 (68.9)
Deferasirox	11 (24.4)
Combination deferiprone + deferasirox	1 (2.2)
Pre-transfusion hemoglobin (current research), mean (SD)	7.7 (1.5)
<7 g/dl, n (%)	9 (20.0)
7–9 g/dl, n (%)	23 (51.1)
> 9 g/dl, n (%)	13 (28.9)
Mean Hb pre-transfusions per year, median (IQR)	8 (1.1)
<7 g/dl, n (%)	9 (20.0)
7–9 g/dl, n (%)	32 (71.1)
> 9 g/dl, n (%)	4 (8.9)
AST U/L mean (SD)	33.3 (19.4)
ALT U/L mean (SD)	28.8 (21.1)
MRI T2* liver ms, median (IQR)	1.6 (1.64)
LIC mg iron/g dry weight liver, mean (SD)	15.36 (7.37)
Liver elastography, kPa mean (SD)	7.7 (3.8)

Abbreviations: AST, aspartate transaminase; ALT, alanine aminotransferase; hsCRP, high-sensitive C-reactive protein; MRI, magnetic resonance imaging; LIC, liver iron concentration; IQR, inter quartile range; SD, standard deviation.

Table 3 Liver MRI T2* and LIC Result

Variables	N (%)
Liver MRI T2*	45
Light hemosiderosis (3,8–11 ms)	5 (11.1)
Moderate hemosiderosis (1,8–3,8 ms)	18 (40.0)
Severe hemosiderosis (<1,8 ms)	22 (48.9)
LIC values based on liver MRI T2*	45
Mild iron overload (2–7 mg/g)	6 (11.3)
Moderate iron overload (7–15 mg/g)	17 (37.8)
Severe iron overload (>15 mg/g)	22 (49.9)

Abbreviations: MRI, magnetic resonance imaging; LIC, liver iron concentration.

Figure 1 Correlation between serum ferritin and liver elastography.

Figure 2 Correlation between liver iron concentration (LIC) and liver elastography.

Figure 3 Correlation between MRI T2* and liver elastography.