Figures & data
Figure 1 Patient selection for the VWD and non-VWD study cohorts with major surgeries.
Notes: Surgeries to treat VWD included uterine ablation, nasal ablation, and hysterectomy. The index date was defined as the date preceding the admission date for the first major surgery for cases identified in the hospital or as the date preceding the date of the first procedure for major surgery for cases identified in other settings.
Abbreviation: VWD, von Willebrand disease.
Table 1 Baseline Demographic and Clinical Characteristics of the VWD and Non-VWD Cohorts
Figure 2 Comparison of all-cause HCRU in the 12-month observation period between matched cohorts of patients with and without VWD who had major surgery, showing (A) proportion of patients by visit type and (B) number of visits per patient by visit type.
Notes: HCRU was measured during the observation period, defined as the 12-month period beginning from the index date. ORs were evaluated for binary variables (ie, at least one visit) using logistic regression. IRRs were evaluated for count variables (ie, number of visits and total length of inpatient stay) using Poisson regression. Models were controlled for age, sex, region, health plan, index year, CCI, comorbidity (anemia, anxiety, depression, fatigue, and obesity), and HCRU (inpatient, ER, and outpatient) during the baseline period. ORs >1 indicate higher odds for patients with VWD and major surgeries compared with propensity score matched patients without VWD who had major surgeries. IRRs >1 indicate increased incidence rate for patients with VWD and major surgeries compared with propensity score matched patients without VWD who had major surgeries. Inpatient visits were identified with a service location of inpatient hospital; ER visits were identified with a service location of emergency department; and outpatient visits were identified with a service location of clinic, office, or outpatient hospital.
Abbreviations: CCI, Charlson Comorbidity Index; CI, confidence interval; ER, emergency room; HCRU, healthcare resource utilization; IRR, incidence rate ratio; OR, odds ratio; VWD, von Willebrand disease.
Figure 3 Comparison of adjusted healthcare costs in the 12-month observation period between matched cohorts of patients with and without VWD who had major surgery.
Notes: Healthcare costs were measured during the observation period, defined as the 12-month period beginning from the index date. All costs were measured as reimbursed amounts from payers to healthcare providers and adjusted to 2018 US dollars using the medical component of the Consumer Price Index. Predicted means for all costs were estimated using a generalized linear model with a gamma distribution and log link. All models were controlled for age, sex, region, health plan, index year, CCI, comorbidity (anemia, anxiety, depression, fatigue, and obesity), and HCRU (inpatient, ER, and outpatient) during the baseline period.
Abbreviations: CCI, Charlson Comorbidity Index; ER, emergency room; HCRU, healthcare resource utilization; VWD, von Willebrand disease.
