The Correlation Between Iron Overload and Endocrine Function in Adult Transfusion-Dependent Beta-Thalassemia Patients with Growth Retardation

Figures & data

Table 1 Baseline Characteristics of Research Subject

Variables	N = 58
Gender, n (%)
Male	31 (53.4)
Female	27 (46.6)
Diagnosis, n (%)
Homozygous Beta Thalassemia	31 (53.4)
HbE Beta Thalassemia	27 (46.6)
Age (years), median (min-max)	21 (18–24)
Pre-transfusion hemoglobin, mean (SD)	8.98 (1.15)
Weight (kg), median (min-max)	40.9 (27–60)
BMI (kg/m^2), median (min-max)	18.79 (14.60–76.18)
Height (cm), mean (SD)	149.05 (8.47)
Mid Parental Height/MPH (cm), mean (SD)	161.25 (9.21)
Serum ferritin (ng/mL), median (min-max)	5,340 (355–22,352)
Transferrin saturation (%), median (min-max)	100 (9–107)
TSHs (mu/L), median (min-max)	3.36 (0.66–8.4)
fT4 (ng/dL), median (min-max))	1.11 (0.76–1.96)
IGF-I (ng/mL), median (min-max)	60.5 (24–206)
MRI T2 * Pancreas, median (min-max)	13.41 (3.96–57.4)

Abbreviations: SD, standard deviation; TSHs, thyroid stimulating hormone-sensitive; FT4, free T4; IGF-1, insulin-like growth factor-1; MRI, magnetic resonance imaging.

Table 2 Proportion of Endocrine Function in Adult Beta TDT Patients with Growth Retardation

Variables	n (%)
Euthyroid or normal	39 (67.3)
Hypothyroidism	0
Subclinical hypothyroidism	19 (32.7)
IGF-I
Normal	12 (20.7)
Low	46 (79.3)

Abbreviations: TDT, transfusion dependent thalassemia; IGF-1, insulin-like growth factor-1.

Table 3 Correlation Between Transferrin Saturation with TSH, fT4 and IGF-1

Variables	R	P
Transferrin saturation-TSHs	0.003	0.492
Transferrin saturation-FT4	0.018	0.448
Transferrin saturation-IGF1	−0.142	0.143

Abbreviations: TSHs, thyroid stimulating hormone-sensitive; FT4, free T4; IGF-1, insulin-like growth factor-1.

Table 4 The Correlation Between Serum Ferritin with TSH, fT4 and IGF-1

Variables	r	p
Serum ferritin-TSHs	0.074	0.290
Serum ferritin -FT4	−0.361	0.003*
Serum ferritin -IGF1	−0.313	0.008*

Abbreviations: TSHs, thyroid stimulating hormone-sensitive; FT4, free T4; IGF-1, insulin-like growth factor-1.Note: *p<0.05.