Catha edulis Forsk and Ascorbic Acid Effects on Hematological Indices in Rat

Figures & data

Figure 1 Effects of Catha edulis Forsk on HgpRBC, NEUT, and NLR in Rats. Each bar represents the mean ± SEM of these indices in rats received AA, T80W, and khat. **Statistical difference at p < 0.01 and *Statistical difference at p < 0.05 when rats received CEF, AA and T80W were compared to each other.

Abbreviations: CEF, Catha edulis Forsk; AA, ascorbic acid; HgpRBC, hemoglobin concentration per red blood cell; NEUT, neutrocyte; NLR, neutrocyte to lymphocyte ratio.

Table 1 Effect of Catha edulis Forsk and Ascorbic Acid on Hematological Indices

Parameter	Group
	T80W	AA200 mg/kg	Ce100 mg/kg	Ce200 mg/kg	Ce300 mg/kg	ChJ2.5 mL/kg
WBC(10^3/μL)	9.06±0.56	10.57±1.83	7.02±0.68	6.91±0.82	8.20±1.01	8.25±1.03
MONO (%)	4.07±0.43	4.53±0.83	3.88±0.49	3.00±0.46	2.97±0.10	3.33±0.64
EO (%)	0.89±0.21	1.30±0.54	0.50±0.05	1.12±0.07	0.63±0.09	0.67±0.06
BASO (%)	0.30±0.04	0.10±0.04	0.17±0.06	0.18±0.04	0.25±0.12	0.15±0.03
NEUT	9.23±0.55	12.06±1.08	27.37±5.60***^ee	12.87±1.50	11.42±1.99	15.32±0.78
LYMP (%)	84.42±3.21	82.65±2.35	68.42±6.40*	82.48±1.76	86.20±2.97	80.28±2.31
NLR (%)	10.99±0.76	14.79±1.74	44.96±10.92***^ee	15.79±2.14	13.39±2.67	19.25±1.41
RBC (10^6/μL)	8.75±0.16	6.66±1.21	9.28±0.47	8.84±0.218	9.17±0.48	6.55±1.21
Hg (g/dL)	16.95±0.26	12.22±2.08	16.93±0.48	15.80±.52	17.10±0.51	11.53±2.30
RBCs (%)	48.46±0.59	35.07±5.78	48.88±1.11	45.77±0.71	48.28±0.72	34.88±6.19
sRBCs (fL)	54.13±0.49	59.24±2.48	53.38±0.42 ^e	53.05±0.98 ^e	52.28±0.48^e	57.08±1.76
HgpRBC (pg)	18.94±0.05	18.47±0.46	18.42±0.46	18.37±0.48	18.67±0.47	17.78±0.58
HgpRBCs (g/dL)	35.13±0.24	33.01±0.99	34.53±0.75	34.50±0.94	35.40±0.49	31.42±1.30*
RsV(fL)	31.73±0.56	34.11±0.55*	33.38±0.56	31.31±0.32	34.02±0.75*	30.92±0.29
PLT(10^3/μL)	476.83±22.	381.83±102.6	509.00±111.7	543.17±90.9	607.33±126.3	379.17±119.1
PCT (%)	0.35±0.03	0.38±0.08	0.65±0.03*^e	0.43±0.07	0.65±0.03*^e	0.37±0.08
aPs(fL)	8.39±0.24	8.90±0.47	8.29±0.08	8.11±0.06	11.37±.1.36*	8.90±0.92
PsV(fL)	9.28±0.26	10.28±0.21*	9.30±0.10	8.95±0.28	10.89±0.51**	9.33±0.08
P-LCR (%)	13.48±0.87	18.79±0.8**	13.28±0.91^e	12.48±0.74^e	13.47±0.86^e	18.01±1.15*

Notes: Hematological indices in rats (n= 6/group) receivedT80W, AA 200mg/kg, Ce(100 mg/kg, 200 mg/kg, and 300 mg/kg) and ChJ 2.5 mL/kg represented as mean ± SEM of. ***Statistical difference at p < 0.001; **Statistical difference at p< 0.01 and *Statistical difference at p < 0.05 when rats received Ce100mg/kg, Ce200mg/kg, Ce300mg/kg, ChJ 2.5 mL/kg and AA 200mg/kg were compared with rats received T80W. ^eestatistical difference at p <0.01 and ^estatistical difference at p <0.05 when rats received Ce100 mg/kg, Ce200 mg/kg, Ce300 mg/kg, ChJ 2.5 mL/kg were compared with rats received AA 200mg/kg.

Abbreviations: Ce, Catha edulis Forsk extract; μL, microliter; sRBCs, size of red blood cells; dL, deciliter; fL, femtoliter; NEUT, Neutrocytes; pg, picogram; NLR, Neut to Lymph ratio; Hg, hemoglobin; HgpRBC, hemoglobin concentration per red blood cell; HgpvRBCs, hemoglobin concentration per volume of red blood cells; PCT, plateletcrit; RsV, red blood cell size variability; PsV, platelet size variability; aPs, average platelet size; P-LCR, platelet-large cell ratio; T80W, tween 80 in distilled water; mg/kg, milligram/kilogram; AA, ascorbic acid; khJ, Catha edulis Forsk juice.